The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Kang Chang; Jian Qin Chen; Yan Xia Shi; Mei Jian Sun; Peng Fei Li; Zhen Jiang Zhao; Wei Ping Zhu; Hong Lin Li; Yu Fang Xu; Bao Ju Li; Xu Hong Qian

doi:10.1016/j.cclet.2017.02.004

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Kang Chang
, Jian Qin Chen
, Yan Xia Shi
, Mei Jian Sun
, Peng Fei Li
, Zhen Jiang Zhao
, Wei Ping Zhu
, Hong Lin Li
, Yu Fang Xu^*
, Bao Ju Li
, Xu Hong Qian

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1’-position and 5’-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.

Original language	English
Pages (from-to)	919-926
Number of pages	8
Journal	Chinese Chemical Letters
Volume	28
Issue number	4
DOIs	https://doi.org/10.1016/j.cclet.2017.02.004
State	Published - 1 Apr 2017
Externally published	Yes

Keywords

Benzotriazole
Plant activator
Salicylic acid
Systemic acquired resistance
Virtual screening

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10.1016/j.cclet.2017.02.004

Cite this

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title = "The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole",

abstract = "Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1{\textquoteright}-position and 5{\textquoteright}-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.",

keywords = "Benzotriazole, Plant activator, Salicylic acid, Systemic acquired resistance, Virtual screening",

author = "Kang Chang and Chen, \{Jian Qin\} and Shi, \{Yan Xia\} and Sun, \{Mei Jian\} and Li, \{Peng Fei\} and Zhao, \{Zhen Jiang\} and Zhu, \{Wei Ping\} and Li, \{Hong Lin\} and Xu, \{Yu Fang\} and Li, \{Bao Ju\} and Qian, \{Xu Hong\}",

note = "Publisher Copyright: {\textcopyright} 2017",

year = "2017",

month = apr,

day = "1",

doi = "10.1016/j.cclet.2017.02.004",

language = "英语",

volume = "28",

pages = "919--926",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "4",

}

TY - JOUR

T1 - The discovery of new scaffold of plant activators

T2 - From salicylic acid to benzotriazole

AU - Chang, Kang

AU - Chen, Jian Qin

AU - Shi, Yan Xia

AU - Sun, Mei Jian

AU - Li, Peng Fei

AU - Zhao, Zhen Jiang

AU - Zhu, Wei Ping

AU - Li, Hong Lin

AU - Xu, Yu Fang

AU - Li, Bao Ju

AU - Qian, Xu Hong

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1’-position and 5’-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.

AB - Started from salicylic acid (SA) and related commercialized plant activators, based on molecular three-dimensional shape and pharmacophore similarity comparison (SHAFTS), a new lead compound benzotriazole was predicted and a series of benzotriazole derivatives were designed and synthesized. The bioassay showed that benzotriazole had high activity against a broad spectrum of diseases including fungi and oomycetes in vivo, but no activity in vitro. And the introduction of proper groups at the 1’-position and 5’-position was beneficial to the activity. So, they had the potential to be exploited as novel plant activators.

KW - Benzotriazole

KW - Plant activator

KW - Salicylic acid

KW - Systemic acquired resistance

KW - Virtual screening

UR - https://www.scopus.com/pages/publications/85015740691

U2 - 10.1016/j.cclet.2017.02.004

DO - 10.1016/j.cclet.2017.02.004

M3 - 文章

AN - SCOPUS:85015740691

SN - 1001-8417

VL - 28

SP - 919

EP - 926

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 4

ER -

The discovery of new scaffold of plant activators: From salicylic acid to benzotriazole

Abstract

Keywords

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