The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Shuanhu Gao; Qiaoling Wang; Gelin Wang; Brett Lomenick; Jie Liu; Chih Wei Fan; Lih Wen Deng; Jing Huang; Lawrence Lum; Chuo Chen

doi:10.1055/S-0031-1290460

The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Shuanhu Gao
, Qiaoling Wang
, Gelin Wang
, Brett Lomenick
, Jie Liu
, Chih Wei Fan
, Lih Wen Deng
, Jing Huang
, Lawrence Lum
, Chuo Chen

University of Texas Southwestern Medical Center
University of California at Los Angeles
National University of Singapore

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

Original language	English
Article number	ST-2012-A0436-A
Pages (from-to)	2298-2310
Number of pages	13
Journal	Synlett
Volume	23
Issue number	16
DOIs	https://doi.org/10.1055/S-0031-1290460
State	Published - 2012
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 14 Life Below Water

Keywords

Hedgehog signaling
Natural products
Steroids
Total synthesis
Tubulin

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10.1055/S-0031-1290460

Cite this

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title = "The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids",

abstract = "Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.",

keywords = "Hedgehog signaling, Natural products, Steroids, Total synthesis, Tubulin",

author = "Shuanhu Gao and Qiaoling Wang and Gelin Wang and Brett Lomenick and Jie Liu and Fan, \{Chih Wei\} and Deng, \{Lih Wen\} and Jing Huang and Lawrence Lum and Chuo Chen",

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doi = "10.1055/S-0031-1290460",

language = "英语",

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T1 - The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

AU - Gao, Shuanhu

AU - Wang, Qiaoling

AU - Wang, Gelin

AU - Lomenick, Brett

AU - Liu, Jie

AU - Fan, Chih Wei

AU - Deng, Lih Wen

AU - Huang, Jing

AU - Lum, Lawrence

AU - Chen, Chuo

PY - 2012

Y1 - 2012

N2 - Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

AB - Isolated from the sponge Terpios hoshinota that causes coral black disease, nakiterpiosin was the first C-nor-D-homosteroid discovered from a marine source. We provide in this account an overview of the chemistry and biology of this natural product. We also include a short history of the synthesis of C-nor-D-homosteroids and the results of some unpublished biological studies of nakiterpiosin.

KW - Hedgehog signaling

KW - Natural products

KW - Steroids

KW - Total synthesis

KW - Tubulin

UR - https://www.scopus.com/pages/publications/84866111349

U2 - 10.1055/S-0031-1290460

DO - 10.1055/S-0031-1290460

M3 - 文章

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SN - 0936-5214

VL - 23

SP - 2298

EP - 2310

JO - Synlett

JF - Synlett

IS - 16

M1 - ST-2012-A0436-A

ER -

The chemistry and biology of nakiterpiosin - C-nor-D-homosteroids

Abstract

UN SDGs

Keywords

Access to Document

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