Synthesis of the key intermediate of ramelteon

Shan Bao Yu; Hao Min Liu; Yu Luo; Wei Lu

doi:10.1016/j.cclet.2010.10.021

Synthesis of the key intermediate of ramelteon

Shan Bao Yu
, Hao Min Liu
, Yu Luo
, Wei Lu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me₂S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.

Original language	English
Pages (from-to)	264-267
Number of pages	4
Journal	Chinese Chemical Letters
Volume	22
Issue number	3
DOIs	https://doi.org/10.1016/j.cclet.2010.10.021
State	Published - Mar 2011

Keywords

Asymmetric Michael addition
Ramelteon
Synthesis

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10.1016/j.cclet.2010.10.021

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@article{12659cf771f847f4a13cbff43f99f551,

title = "Synthesis of the key intermediate of ramelteon",

abstract = "Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.",

keywords = "Asymmetric Michael addition, Ramelteon, Synthesis",

author = "Yu, \{Shan Bao\} and Liu, \{Hao Min\} and Yu Luo and Wei Lu",

year = "2011",

month = mar,

doi = "10.1016/j.cclet.2010.10.021",

language = "英语",

volume = "22",

pages = "264--267",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "3",

}

TY - JOUR

T1 - Synthesis of the key intermediate of ramelteon

AU - Yu, Shan Bao

AU - Liu, Hao Min

AU - Luo, Yu

AU - Lu, Wei

PY - 2011/3

Y1 - 2011/3

N2 - Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.

AB - Asymmetric conjugated addition of allylcopper reagents derived from an allyl Grignard reagent and CuBr·Me2S to chiral α,β-unsaturated N-acyl oxazolidinones has been achieved. The synthetic procedure was applied to the preparation of the key intermediate of the novel nonbenzodiazepine hypnotic drug, ramelteon.

KW - Asymmetric Michael addition

KW - Ramelteon

KW - Synthesis

UR - https://www.scopus.com/pages/publications/79451469807

U2 - 10.1016/j.cclet.2010.10.021

DO - 10.1016/j.cclet.2010.10.021

M3 - 文章

AN - SCOPUS:79451469807

SN - 1001-8417

VL - 22

SP - 264

EP - 267

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 3

ER -

Synthesis of the key intermediate of ramelteon

Abstract

Keywords

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