Synthesis of the de synthon of racemic camptothecin

Shanbao Yu; Yu Luo; Haiyan Liu; Haomin Liu; Wei Lu

doi:10.1007/s00706-009-0245-0

Synthesis of the de synthon of racemic camptothecin

Shanbao Yu
, Yu Luo
, Haiyan Liu
, Haomin Liu
, Wei Lu^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

Original language	English
Pages (from-to)	245-249
Number of pages	5
Journal	Monatshefte fur Chemie
Volume	141
Issue number	2
DOIs	https://doi.org/10.1007/s00706-009-0245-0
State	Published - Feb 2010

Keywords

2-Chloronicotinic acid lithiation
Camptothecin
Lactone
Pyridone

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10.1007/s00706-009-0245-0

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title = "Synthesis of the de synthon of racemic camptothecin",

abstract = "A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29\% overall yield.",

keywords = "2-Chloronicotinic acid lithiation, Camptothecin, Lactone, Pyridone",

author = "Shanbao Yu and Yu Luo and Haiyan Liu and Haomin Liu and Wei Lu",

year = "2010",

month = feb,

doi = "10.1007/s00706-009-0245-0",

language = "英语",

volume = "141",

pages = "245--249",

journal = "Monatshefte fur Chemie",

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TY - JOUR

T1 - Synthesis of the de synthon of racemic camptothecin

AU - Yu, Shanbao

AU - Luo, Yu

AU - Liu, Haiyan

AU - Liu, Haomin

AU - Lu, Wei

PY - 2010/2

Y1 - 2010/2

N2 - A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

AB - A concise formal synthesis of camptothecin is described. The key pyrido-lactone (DE ring) was prepared effectively starting from 2-chloronicotinic acid via lithia-tion, reduction, and hydrolysis in 29% overall yield.

KW - 2-Chloronicotinic acid lithiation

KW - Camptothecin

KW - Lactone

KW - Pyridone

UR - https://www.scopus.com/pages/publications/77952582092

U2 - 10.1007/s00706-009-0245-0

DO - 10.1007/s00706-009-0245-0

M3 - 文章

AN - SCOPUS:77952582092

SN - 0026-9247

VL - 141

SP - 245

EP - 249

JO - Monatshefte fur Chemie

JF - Monatshefte fur Chemie

IS - 2

ER -

Synthesis of the de synthon of racemic camptothecin

Abstract

Keywords

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