Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

Wei Gang Huang; Jing Ya Li; Yu Luo; Jia Li; Wei Lu

doi:10.1016/j.cclet.2009.07.008

Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

Wei Gang Huang
, Jing Ya Li
, Yu Luo^*
, Jia Li
, Wei Lu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

CAS - Shanghai Institute of Materia Medica
East China Normal University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC₅₀ values in very low micromolar range. At last, the preliminary SAR was discussed.

Original language	English
Pages (from-to)	1461-1464
Number of pages	4
Journal	Chinese Chemical Letters
Volume	20
Issue number	12
DOIs	https://doi.org/10.1016/j.cclet.2009.07.008
State	Published - Dec 2009

Keywords

Antitumor
Cdc25 phosphatases
Synthesis
Tanshinone IIA

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10.1016/j.cclet.2009.07.008

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@article{b058dff84abb4d828cdc6e55dd2f5252,

title = "Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases",

abstract = "Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.",

keywords = "Antitumor, Cdc25 phosphatases, Synthesis, Tanshinone IIA",

author = "Huang, \{Wei Gang\} and Li, \{Jing Ya\} and Yu Luo and Jia Li and Wei Lu",

year = "2009",

month = dec,

doi = "10.1016/j.cclet.2009.07.008",

language = "英语",

volume = "20",

pages = "1461--1464",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

AU - Huang, Wei Gang

AU - Li, Jing Ya

AU - Luo, Yu

AU - Li, Jia

AU - Lu, Wei

PY - 2009/12

Y1 - 2009/12

N2 - Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.

AB - Two series of tanshinone IIA derivatives were synthesized and evaluated for their antitumor activities as Cdc25 phosphatase inhibitors. Most of them demonstrated potent Cdc25 inhibitory activity and powerful cytotoxicity against A549 tumor cell line, producing IC50 values in very low micromolar range. At last, the preliminary SAR was discussed.

KW - Antitumor

KW - Cdc25 phosphatases

KW - Synthesis

KW - Tanshinone IIA

UR - https://www.scopus.com/pages/publications/70349994100

U2 - 10.1016/j.cclet.2009.07.008

DO - 10.1016/j.cclet.2009.07.008

M3 - 文章

AN - SCOPUS:70349994100

SN - 1001-8417

VL - 20

SP - 1461

EP - 1464

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 12

ER -

Synthesis of tanshinone IIA analogues and their inhibitory activities against Cdc25 phosphatases

Abstract

Keywords

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