Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake

Yannan Yang; Surajit Karmakar; Jun Zhang; Meihua Yu; Neena Mitter; Chengzhong Yu

doi:10.1039/c4tb00595c

Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake

Yannan Yang, Surajit Karmakar, Jun Zhang, Meihua Yu, Neena Mitter, Chengzhong Yu

University of Queensland

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Small sized SBA-15 rods with 80-200 nm in length, 18 ± 8 nm in width and a pore size of 8.3 nm have been successfully synthesized by finely tuning the synthesis pH in a narrow range of 3.40-3.88. Compared to traditional SBA-15 with relatively larger particle sizes and MCM-41 with smaller pore sizes, SBA-15 rods prepared in this study demonstrate higher adsorption capacity towards large protein molecules such as bovine serum albumin and lysozyme, and enhanced cellular uptake efficiency in human osteosarcoma cancer cells. This novel silica material with small particle sizes, large pores as well as excellent biocompatibility is a promising delivery system for the cellular delivery of large molecular weight therapeutic agents with improved efficacy. This journal is

Original language	English
Pages (from-to)	4929-4934
Number of pages	6
Journal	Journal of Materials Chemistry B
Volume	2
Issue number	30
DOIs	https://doi.org/10.1039/c4tb00595c
State	Published - 14 Aug 2014
Externally published	Yes

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10.1039/c4tb00595c

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AU - Yang, Yannan

AU - Karmakar, Surajit

AU - Zhang, Jun

AU - Yu, Meihua

AU - Mitter, Neena

AU - Yu, Chengzhong

PY - 2014/8/14

Y1 - 2014/8/14

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AB - Small sized SBA-15 rods with 80-200 nm in length, 18 ± 8 nm in width and a pore size of 8.3 nm have been successfully synthesized by finely tuning the synthesis pH in a narrow range of 3.40-3.88. Compared to traditional SBA-15 with relatively larger particle sizes and MCM-41 with smaller pore sizes, SBA-15 rods prepared in this study demonstrate higher adsorption capacity towards large protein molecules such as bovine serum albumin and lysozyme, and enhanced cellular uptake efficiency in human osteosarcoma cancer cells. This novel silica material with small particle sizes, large pores as well as excellent biocompatibility is a promising delivery system for the cellular delivery of large molecular weight therapeutic agents with improved efficacy. This journal is

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Synthesis of SBA-15 rods with small sizes for enhanced cellular uptake

Abstract

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