Synthesis of piperazine derivatives containing pyridinemethyl/ thiazolemethyl and their biological activities

Gang Yue Li; Sheng Gang Yan; Shan Jiang; Xu Hong Qian; Qing Chun Huang; Rong Zhang

Synthesis of piperazine derivatives containing pyridinemethyl/ thiazolemethyl and their biological activities

Gang Yue Li^*
, Sheng Gang Yan
, Shan Jiang
, Xu Hong Qian
, Qing Chun Huang
, Rong Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

According to the principle of combination of active groups, a series of piperazine derivatives containing pyridinemethyl/thiazolemethyl were designed and synthesized from 2-chloro-5-(chloromethyl) pyridine or 2-chloro-5- (chloromethyl)thiazole via N-alkylation and addition reactions. Some compounds showed weak herbicidal activity and insecticidal activity against Aphis fabae but good insecticidal activity against Culex pipiens, among which compound 4f exhibited 100% mortality against Culex pipiens at 50 mg/L.

Original language	English
Pages (from-to)	2001-2006
Number of pages	6
Journal	Chinese Journal of Organic Chemistry
Volume	28
Issue number	11
State	Published - Nov 2008
Externally published	Yes

Keywords

Biological activity
Piperazine derivative
Synthesis

Cite this

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title = "Synthesis of piperazine derivatives containing pyridinemethyl/ thiazolemethyl and their biological activities",

abstract = "According to the principle of combination of active groups, a series of piperazine derivatives containing pyridinemethyl/thiazolemethyl were designed and synthesized from 2-chloro-5-(chloromethyl) pyridine or 2-chloro-5- (chloromethyl)thiazole via N-alkylation and addition reactions. Some compounds showed weak herbicidal activity and insecticidal activity against Aphis fabae but good insecticidal activity against Culex pipiens, among which compound 4f exhibited 100\% mortality against Culex pipiens at 50 mg/L.",

keywords = "Biological activity, Piperazine derivative, Synthesis",

author = "Li, \{Gang Yue\} and Yan, \{Sheng Gang\} and Shan Jiang and Qian, \{Xu Hong\} and Huang, \{Qing Chun\} and Rong Zhang",

year = "2008",

month = nov,

language = "英语",

volume = "28",

pages = "2001--2006",

journal = "Chinese Journal of Organic Chemistry",

issn = "0253-2786",

publisher = "Science Press ",

number = "11",

}

TY - JOUR

T1 - Synthesis of piperazine derivatives containing pyridinemethyl/ thiazolemethyl and their biological activities

AU - Li, Gang Yue

AU - Yan, Sheng Gang

AU - Jiang, Shan

AU - Qian, Xu Hong

AU - Huang, Qing Chun

AU - Zhang, Rong

PY - 2008/11

Y1 - 2008/11

N2 - According to the principle of combination of active groups, a series of piperazine derivatives containing pyridinemethyl/thiazolemethyl were designed and synthesized from 2-chloro-5-(chloromethyl) pyridine or 2-chloro-5- (chloromethyl)thiazole via N-alkylation and addition reactions. Some compounds showed weak herbicidal activity and insecticidal activity against Aphis fabae but good insecticidal activity against Culex pipiens, among which compound 4f exhibited 100% mortality against Culex pipiens at 50 mg/L.

AB - According to the principle of combination of active groups, a series of piperazine derivatives containing pyridinemethyl/thiazolemethyl were designed and synthesized from 2-chloro-5-(chloromethyl) pyridine or 2-chloro-5- (chloromethyl)thiazole via N-alkylation and addition reactions. Some compounds showed weak herbicidal activity and insecticidal activity against Aphis fabae but good insecticidal activity against Culex pipiens, among which compound 4f exhibited 100% mortality against Culex pipiens at 50 mg/L.

KW - Biological activity

KW - Piperazine derivative

KW - Synthesis

UR - https://www.scopus.com/pages/publications/59749094900

M3 - 文章

AN - SCOPUS:59749094900

SN - 0253-2786

VL - 28

SP - 2001

EP - 2006

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 11

ER -

Synthesis of piperazine derivatives containing pyridinemethyl/ thiazolemethyl and their biological activities

Abstract

Keywords

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