Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

Sitian Feng; Yitian Tang; Chenjue Yang; Chaoren Shen; Kaiwu Dong

doi:10.1021/acs.orglett.0c02700

Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

Sitian Feng, Yitian Tang, Chenjue Yang, Chaoren Shen, Kaiwu Dong

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.

Original language	English
Pages (from-to)	7508-7512
Number of pages	5
Journal	Organic Letters
Volume	22
Issue number	19
DOIs	https://doi.org/10.1021/acs.orglett.0c02700
State	Published - 2 Oct 2020

Access to Document

10.1021/acs.orglett.0c02700

Cite this

@article{4a1c892248c34ef683aea0621e0a78a2,

title = "Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation",

abstract = "Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepared in high yields (83-99\%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.",

author = "Sitian Feng and Yitian Tang and Chenjue Yang and Chaoren Shen and Kaiwu Dong",

note = "Publisher Copyright: {\textcopyright} 2020 American Chemical Society.",

year = "2020",

month = oct,

day = "2",

doi = "10.1021/acs.orglett.0c02700",

language = "英语",

volume = "22",

pages = "7508--7512",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "19",

}

TY - JOUR

T1 - Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

AU - Feng, Sitian

AU - Tang, Yitian

AU - Yang, Chenjue

AU - Shen, Chaoren

AU - Dong, Kaiwu

PY - 2020/10/2

Y1 - 2020/10/2

N2 - Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.

AB - Synthesis of optically active gem-difluorinated organic molecules attracts a great deal of interest due to their unique properties in pharmaceutical and agrochemical areas. Herein, a series of enantioenriched α,α-difluoro-β-arylbutanoic esters were prepared in high yields (83-99%) with moderate to excellent enantioselectivities (≤97:3 er) by palladium-catalyzed asymmetric hydrogenation.

UR - https://www.scopus.com/pages/publications/85092058807

U2 - 10.1021/acs.orglett.0c02700

DO - 10.1021/acs.orglett.0c02700

M3 - 文章

C2 - 32945684

AN - SCOPUS:85092058807

SN - 1523-7060

VL - 22

SP - 7508

EP - 7512

JO - Organic Letters

JF - Organic Letters

IS - 19

ER -

Synthesis of Enantioenriched α,α-Difluoro-β-arylbutanoic Esters by Pd-Catalyzed Asymmetric Hydrogenation

Abstract

Access to Document

Other files and links

Fingerprint

Cite this