Synthesis of cytotoxic sinapyl alcohol derivatives from Ligularia nelumbifolia

Yu Zhao; Wei Lu; Xiao Jiang Hao; Jun Chao Cai; Hong Yu; Thierry Sevenet; Françoise Guéritte

Synthesis of cytotoxic sinapyl alcohol derivatives from Ligularia nelumbifolia

Yu Zhao, Wei Lu, Xiao Jiang Hao, Jun Chao Cai, Hong Yu, Thierry Sevenet, Françoise Guéritte

Zhejiang University

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.

Original language	English
Pages (from-to)	201-204
Number of pages	4
Journal	Chinese Chemical Letters
Volume	13
Issue number	3
State	Published - Mar 2002
Externally published	Yes

Keywords

Cytotoxicity
Natural products
Pharmaceutical chemistry
SAR
Sinapyl alcohol derivatives
Total synthesis

Cite this

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title = "Synthesis of cytotoxic sinapyl alcohol derivatives from Ligularia nelumbifolia",

abstract = "Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.",

keywords = "Cytotoxicity, Natural products, Pharmaceutical chemistry, SAR, Sinapyl alcohol derivatives, Total synthesis",

author = "Yu Zhao and Wei Lu and Hao, \{Xiao Jiang\} and Cai, \{Jun Chao\} and Hong Yu and Thierry Sevenet and Fran{\c c}oise Gu{\'e}ritte",

year = "2002",

month = mar,

language = "英语",

volume = "13",

pages = "201--204",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

number = "3",

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TY - JOUR

T1 - Synthesis of cytotoxic sinapyl alcohol derivatives from Ligularia nelumbifolia

AU - Zhao, Yu

AU - Lu, Wei

AU - Hao, Xiao Jiang

AU - Cai, Jun Chao

AU - Yu, Hong

AU - Sevenet, Thierry

AU - Guéritte, Françoise

PY - 2002/3

Y1 - 2002/3

N2 - Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.

AB - Total synthesis of two cytotoxic natural products, nelumol A (1) and nelumal A (2), were carried out by two different paths. 4-O-Benzyl substitute analogues 26 and 27, as well as the 4-O-(2-methyl-butenyl) derivatives 29 and 30 were also synthesized for a SAR investigation. 1 and 2 were also measured on different tumor cell line.

KW - Cytotoxicity

KW - Natural products

KW - Pharmaceutical chemistry

KW - SAR

KW - Sinapyl alcohol derivatives

KW - Total synthesis

UR - https://www.scopus.com/pages/publications/0036004940

M3 - 文章

AN - SCOPUS:0036004940

SN - 1001-8417

VL - 13

SP - 201

EP - 204

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 3

ER -

Synthesis of cytotoxic sinapyl alcohol derivatives from Ligularia nelumbifolia

Abstract

Keywords

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