Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage

Yajie Yang; Jiaqi Huang; Hailu Tan; Lingkai Kong; Mengdan Wang; Yang Yuan; Yanzhong Li

doi:10.1039/c8ob03031f

Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage

Yajie Yang
, Jiaqi Huang
, Hailu Tan
, Lingkai Kong
, Mengdan Wang
, Yang Yuan
, Yanzhong Li^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs ₂ CO ₃ promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp ² C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.

Original language	English
Pages (from-to)	958-965
Number of pages	8
Journal	Organic and Biomolecular Chemistry
Volume	17
Issue number	4
DOIs	https://doi.org/10.1039/c8ob03031f
State	Published - 2019

Access to Document

10.1039/c8ob03031f

Cite this

@article{a15718473eae4154b97f655410bd2173,

title = "Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage",

abstract = " A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs 2 CO 3 promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp 2 C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.",

author = "Yajie Yang and Jiaqi Huang and Hailu Tan and Lingkai Kong and Mengdan Wang and Yang Yuan and Yanzhong Li",

note = "Publisher Copyright: {\textcopyright} 2019 The Royal Society of Chemistry.",

year = "2019",

doi = "10.1039/c8ob03031f",

language = "英语",

volume = "17",

pages = "958--965",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "4",

}

TY - JOUR

T1 - Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage

AU - Yang, Yajie

AU - Huang, Jiaqi

AU - Tan, Hailu

AU - Kong, Lingkai

AU - Wang, Mengdan

AU - Yuan, Yang

AU - Li, Yanzhong

PY - 2019

Y1 - 2019

N2 - A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs 2 CO 3 promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp 2 C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.

AB - A highly efficient protocol for the synthesis of polysubstituted cyano carbazoles has been developed. This process is realized through the tandem reactions of Cs 2 CO 3 promoted C-C σ-bond activation of α-cyano ketones followed by Fe-catalyzed selective C-H and/or C-C bond activations. Two of the sp 2 C-H bonds are functionalized, and two of the C-C σ-bonds are cleaved involving a 1,2-acyl migration during the reaction process.

UR - https://www.scopus.com/pages/publications/85060398036

U2 - 10.1039/c8ob03031f

DO - 10.1039/c8ob03031f

M3 - 文章

C2 - 30631868

AN - SCOPUS:85060398036

SN - 1477-0520

VL - 17

SP - 958

EP - 965

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 4

ER -

Synthesis of cyano-substituted carbazoles via successive C-C/C-H cleavage

Abstract

Access to Document

Other files and links

Fingerprint

Cite this