Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

Weichen Wang; Chaoren Shen; Linli Zhang; Kaiwu Dong

doi:10.1021/acs.orglett.3c04004

Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

Weichen Wang
, Chaoren Shen
, Linli Zhang
, Kaiwu Dong^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.

Original language	English
Pages (from-to)	850-854
Number of pages	5
Journal	Organic Letters
Volume	26
Issue number	4
DOIs	https://doi.org/10.1021/acs.orglett.3c04004
State	Published - 2 Feb 2024

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10.1021/acs.orglett.3c04004

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title = "Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate",

abstract = "Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.",

author = "Weichen Wang and Chaoren Shen and Linli Zhang and Kaiwu Dong",

note = "Publisher Copyright: {\textcopyright} 2024 American Chemical Society.",

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doi = "10.1021/acs.orglett.3c04004",

language = "英语",

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T1 - Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

AU - Wang, Weichen

AU - Shen, Chaoren

AU - Zhang, Linli

AU - Dong, Kaiwu

PY - 2024/2/2

Y1 - 2024/2/2

N2 - Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.

AB - Photoredox/nickel-catalyzed enantioconvergent acyl cross-coupling of carboxylic derivatives with racemic secondary organotrifluoroborate was developed for the synthesis of an enolizable chiral α-aryl ketone under mild neutral conditions. Moderate to high yields and good enantioselectivities were achieved.

UR - https://www.scopus.com/pages/publications/85184282684

U2 - 10.1021/acs.orglett.3c04004

DO - 10.1021/acs.orglett.3c04004

M3 - 文章

C2 - 38251833

AN - SCOPUS:85184282684

SN - 1523-7060

VL - 26

SP - 850

EP - 854

JO - Organic Letters

JF - Organic Letters

IS - 4

ER -

Synthesis of Chiral α-Aryl Ketones by Photoredox/Nickel-Catalyzed Enantioconvergent Acyl Cross-Coupling with Organotrifluoroborate

Abstract

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