Abstract
Artabotrine 1 is a novel N-methoxylated 4,5-dioxoaporphine alkaloid which has been reported to be cytotoxic against P-388 cells. The total synthesis of 1 was carried out, and one of its analogue, N-methoxycepharadione B 2, was also synthesized. Both of the alkaloids and several intermediates were cytotoxic to several selected tumor cell lines.
| Original language | English |
|---|---|
| Pages (from-to) | 5-8 |
| Number of pages | 4 |
| Journal | Chinese Chemical Letters |
| Volume | 17 |
| Issue number | 1 |
| State | Published - Jan 2006 |
| Externally published | Yes |
Keywords
- Aporphine alkaloid
- Artabotrine
- Cytotoxicity
- Synthesis