Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

Hui Peng; Lijuan Zhang; John Spires; Christian Soeller; Jadranka Travas-Sejdic

doi:10.1016/j.polymer.2007.04.029

Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

Hui Peng
, Lijuan Zhang
, John Spires
, Christian Soeller
, Jadranka Travas-Sejdic^*

^*Corresponding author for this work

The University of Auckland

Research output: Contribution to journal › Article › peer-review

59 Scopus citations

Abstract

The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

Original language	English
Pages (from-to)	3413-3419
Number of pages	7
Journal	Polymer
Volume	48
Issue number	12
DOIs	https://doi.org/10.1016/j.polymer.2007.04.029
State	Published - 4 Jun 2007
Externally published	Yes

Keywords

Conducting polymers
DNA sensor
Electropolymerisation

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10.1016/j.polymer.2007.04.029

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title = "Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor",

abstract = "The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.",

keywords = "Conducting polymers, DNA sensor, Electropolymerisation",

author = "Hui Peng and Lijuan Zhang and John Spires and Christian Soeller and Jadranka Travas-Sejdic",

year = "2007",

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doi = "10.1016/j.polymer.2007.04.029",

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TY - JOUR

T1 - Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

AU - Peng, Hui

AU - Zhang, Lijuan

AU - Spires, John

AU - Soeller, Christian

AU - Travas-Sejdic, Jadranka

PY - 2007/6/4

Y1 - 2007/6/4

N2 - The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

AB - The synthesis of a new functionalized terthiophene monomer with an unsaturated side chain, 3-((2′:2″,5″:2‴-terthiophene)-3″-yl) acrylic acid, is described. A conducting polymer was obtained by electropolymerization of the functionalized monomer. The properties of the polymer were investigated using FT-IR, Raman and UV-vis spectroscopy. The application of the polymer as an active substrate for a genosensor is demonstrated by the covalent attachment of amino-end modified oligonucleotide probes to the carboxylic acid group of the polymer. The hybridization of the complementary ODNs can be clearly detected by an increase in the admittance without the need for an indicator or any sample modifications.

KW - Conducting polymers

KW - DNA sensor

KW - Electropolymerisation

UR - https://www.scopus.com/pages/publications/34248996362

U2 - 10.1016/j.polymer.2007.04.029

DO - 10.1016/j.polymer.2007.04.029

M3 - 文章

AN - SCOPUS:34248996362

SN - 0032-3861

VL - 48

SP - 3413

EP - 3419

JO - Polymer

JF - Polymer

IS - 12

ER -

Synthesis of a functionalized polythiophene as an active substrate for a label-free electrochemical genosensor

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Keywords

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