Synthesis, characterization and cytotoxicity of phosphoryl choline-grafted water-soluble carbon nanotubes

Tao Zhang; Min Xu; Ling He; Kai Xi; Min Gu; Zhengsheng Jiang

doi:10.1016/j.carbon.2008.07.033

Synthesis, characterization and cytotoxicity of phosphoryl choline-grafted water-soluble carbon nanotubes

Tao Zhang^*
, Min Xu
, Ling He
, Kai Xi
, Min Gu
, Zhengsheng Jiang

^*Corresponding author for this work

School of Physics and Electronic Science

Nanjing University
China Pharmaceutical University

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Carbon nanotubes (CNTs) were rendered water-soluble by grafting on phosphoryl choline (PC). The modified CNTs were characterized utilizing Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis, nuclear magnetic resonance, transmission electron microscopy, ultraviolet/visible absorbance spectra and dynamic laser light-scattering. The results show that the target products are easily dispersed in water and remain dispersed for at least three months. This study showed that both CNTs and CNT-PC induce no cytotoxicity on clonal pheochromocytoma cells (PC12) and human colon carcinoma cell lines (Caco-2). The grafted PC group confers water solubility and keeps the cell-compatibility of CNTs.

Original language	English
Pages (from-to)	1782-1791
Number of pages	10
Journal	Carbon
Volume	46
Issue number	13
DOIs	https://doi.org/10.1016/j.carbon.2008.07.033
State	Published - Nov 2008

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title = "Synthesis, characterization and cytotoxicity of phosphoryl choline-grafted water-soluble carbon nanotubes",

abstract = "Carbon nanotubes (CNTs) were rendered water-soluble by grafting on phosphoryl choline (PC). The modified CNTs were characterized utilizing Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis, nuclear magnetic resonance, transmission electron microscopy, ultraviolet/visible absorbance spectra and dynamic laser light-scattering. The results show that the target products are easily dispersed in water and remain dispersed for at least three months. This study showed that both CNTs and CNT-PC induce no cytotoxicity on clonal pheochromocytoma cells (PC12) and human colon carcinoma cell lines (Caco-2). The grafted PC group confers water solubility and keeps the cell-compatibility of CNTs.",

author = "Tao Zhang and Min Xu and Ling He and Kai Xi and Min Gu and Zhengsheng Jiang",

year = "2008",

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doi = "10.1016/j.carbon.2008.07.033",

language = "英语",

volume = "46",

pages = "1782--1791",

journal = "Carbon",

issn = "0008-6223",

publisher = "Elsevier Ltd",

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TY - JOUR

T1 - Synthesis, characterization and cytotoxicity of phosphoryl choline-grafted water-soluble carbon nanotubes

AU - Zhang, Tao

AU - Xu, Min

AU - He, Ling

AU - Xi, Kai

AU - Gu, Min

AU - Jiang, Zhengsheng

PY - 2008/11

Y1 - 2008/11

N2 - Carbon nanotubes (CNTs) were rendered water-soluble by grafting on phosphoryl choline (PC). The modified CNTs were characterized utilizing Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis, nuclear magnetic resonance, transmission electron microscopy, ultraviolet/visible absorbance spectra and dynamic laser light-scattering. The results show that the target products are easily dispersed in water and remain dispersed for at least three months. This study showed that both CNTs and CNT-PC induce no cytotoxicity on clonal pheochromocytoma cells (PC12) and human colon carcinoma cell lines (Caco-2). The grafted PC group confers water solubility and keeps the cell-compatibility of CNTs.

AB - Carbon nanotubes (CNTs) were rendered water-soluble by grafting on phosphoryl choline (PC). The modified CNTs were characterized utilizing Fourier transform infrared spectra, X-ray photoelectron spectra, thermogravimetric analysis, nuclear magnetic resonance, transmission electron microscopy, ultraviolet/visible absorbance spectra and dynamic laser light-scattering. The results show that the target products are easily dispersed in water and remain dispersed for at least three months. This study showed that both CNTs and CNT-PC induce no cytotoxicity on clonal pheochromocytoma cells (PC12) and human colon carcinoma cell lines (Caco-2). The grafted PC group confers water solubility and keeps the cell-compatibility of CNTs.

UR - https://www.scopus.com/pages/publications/52949091516

U2 - 10.1016/j.carbon.2008.07.033

DO - 10.1016/j.carbon.2008.07.033

M3 - 文章

AN - SCOPUS:52949091516

SN - 0008-6223

VL - 46

SP - 1782

EP - 1791

JO - Carbon

JF - Carbon

IS - 13

ER -

Synthesis, characterization and cytotoxicity of phosphoryl choline-grafted water-soluble carbon nanotubes

Abstract

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