TY - JOUR
T1 - Synthesis, antitumor and DNA photocleaving activities of novel naphthalene carboxamides
T2 - Effects of different thio-heterocyclic rings and aminoalkyl side chains
AU - Li, Zhigang
AU - Yang, Qing
AU - Qian, Xuhong
PY - 2005/9/5
Y1 - 2005/9/5
N2 - Two kinds of thio-heterocyclic fused naphthalene carboxamides, 3a-b, 4a-b, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound 3a or 3b, having the thiophene ring, intercalated into DNA more strongly than compound 4a or 4b, having the thioxanthene ring. Compound 4a or 4b, photocleaved DNA more efficiently than 3a or 3b via superoxide anion. Compound 4a was the strongest inhibitor for P388 (murine leukemia cell), while 3a was the most cytotoxic one against A549 (human lung cancer cell). Each new compound showed stronger DNA photocleaving activity than corresponding naphthalimide.
AB - Two kinds of thio-heterocyclic fused naphthalene carboxamides, 3a-b, 4a-b, were designed, synthesized and quantitatively evaluated as efficient antitumor and DNA photocleaving agents. Compound 3a or 3b, having the thiophene ring, intercalated into DNA more strongly than compound 4a or 4b, having the thioxanthene ring. Compound 4a or 4b, photocleaved DNA more efficiently than 3a or 3b via superoxide anion. Compound 4a was the strongest inhibitor for P388 (murine leukemia cell), while 3a was the most cytotoxic one against A549 (human lung cancer cell). Each new compound showed stronger DNA photocleaving activity than corresponding naphthalimide.
KW - Antitumor
KW - DNA photocleavage
KW - Intercalating
UR - https://www.scopus.com/pages/publications/23444439628
U2 - 10.1016/j.tet.2005.06.097
DO - 10.1016/j.tet.2005.06.097
M3 - 文章
AN - SCOPUS:23444439628
SN - 0040-4020
VL - 61
SP - 8711
EP - 8717
JO - Tetrahedron
JF - Tetrahedron
IS - 36
ER -
