Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery

Xiaohua He; Xiaomeng Wu; Chunyan Gao; Kai Wang; Shaoliang Lin; Wei Huang; Meiran Xie; Deyue Yan

doi:10.1016/j.reactfunctpolym.2011.02.001

Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery

Xiaohua He^*
, Xiaomeng Wu
, Chunyan Gao
, Kai Wang
, Shaoliang Lin
, Wei Huang
, Meiran Xie
, Deyue Yan

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by ¹H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. Crown

Original language	English
Pages (from-to)	544-552
Number of pages	9
Journal	Reactive and Functional Polymers
Volume	71
Issue number	5
DOIs	https://doi.org/10.1016/j.reactfunctpolym.2011.02.001
State	Published - May 2011

Keywords

Atom transfer radical polymerization
Block copolymer
Micelles
Poly(N-isopropylacrylamide)
Thermo-responsive

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He, X., Wu, X., Gao, C., Wang, K., Lin, S., Huang, W., Xie, M., & Yan, D. (2011). Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery. Reactive and Functional Polymers, 71(5), 544-552. https://doi.org/10.1016/j.reactfunctpolym.2011.02.001

@article{a2e3ad72cd3f4002b9ff3deb3340f8e9,

title = "Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery",

abstract = "A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. Crown",

keywords = "Atom transfer radical polymerization, Block copolymer, Micelles, Poly(N-isopropylacrylamide), Thermo-responsive",

author = "Xiaohua He and Xiaomeng Wu and Chunyan Gao and Kai Wang and Shaoliang Lin and Wei Huang and Meiran Xie and Deyue Yan",

year = "2011",

month = may,

doi = "10.1016/j.reactfunctpolym.2011.02.001",

language = "英语",

volume = "71",

pages = "544--552",

journal = "Reactive and Functional Polymers",

issn = "1381-5148",

publisher = "Elsevier B.V.",

number = "5",

}

He, X, Wu, X, Gao, C, Wang, K, Lin, S, Huang, W, Xie, M & Yan, D 2011, 'Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery', Reactive and Functional Polymers, vol. 71, no. 5, pp. 544-552. https://doi.org/10.1016/j.reactfunctpolym.2011.02.001

Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery. / He, Xiaohua; Wu, Xiaomeng; Gao, Chunyan et al.
In: Reactive and Functional Polymers, Vol. 71, No. 5, 05.2011, p. 544-552.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery

AU - He, Xiaohua

AU - Wu, Xiaomeng

AU - Gao, Chunyan

AU - Wang, Kai

AU - Lin, Shaoliang

AU - Huang, Wei

AU - Xie, Meiran

AU - Yan, Deyue

PY - 2011/5

Y1 - 2011/5

N2 - A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. Crown

AB - A hydrophilic, thermo-responsive triblock copolymer poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N-isopropylacrylamide) (MPEO-b-PAA-b-PNIPAM) was synthesized by sequential atom transfer radical polymerization and hydrolysis. These polymers were characterized in detail by 1H NMR, FT-IR and gel permeation chromatography. In aqueous solution, MPEO-b-PAA-b-PNIPAM can self-assemble into core-shell-corona micelles above a LCST of the PNIPAM block. Condensation reactions easily cross-link the PAA shells, which enhances micellar stability. Doxorubicin (DOX), a model drug, was loaded into the core of the polymeric micelles and followed a pattern of thermo-sensitive drug release in vitro in cumulative release studies. Crown

KW - Atom transfer radical polymerization

KW - Block copolymer

KW - Micelles

KW - Poly(N-isopropylacrylamide)

KW - Thermo-responsive

UR - https://www.scopus.com/pages/publications/79952323823

U2 - 10.1016/j.reactfunctpolym.2011.02.001

DO - 10.1016/j.reactfunctpolym.2011.02.001

M3 - 文章

AN - SCOPUS:79952323823

SN - 1381-5148

VL - 71

SP - 544

EP - 552

JO - Reactive and Functional Polymers

JF - Reactive and Functional Polymers

IS - 5

ER -

Synthesis and self-assembly of a hydrophilic, thermo-responsive poly(ethylene oxide) monomethyl ether-block-poly(acrylic acid)-block-poly(N- isopropylacrylamide) copolymer to form micelles for drug delivery

Abstract

Keywords

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