Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

Xuhong Qian; Ping Mao; Wei Yao; Xiangfeng Guo

doi:10.1016/S0040-4039(02)00442-2

Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

Xuhong Qian^*
, Ping Mao
, Wei Yao
, Xiangfeng Guo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.

Original language	English
Pages (from-to)	2995-2998
Number of pages	4
Journal	Tetrahedron Letters
Volume	43
Issue number	16
DOIs	https://doi.org/10.1016/S0040-4039(02)00442-2
State	Published - 15 Apr 2002
Externally published	Yes

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title = "Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength",

abstract = "A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.",

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T2 - An efficient 'time-resolved' DNA photocleaver with long-wavelength

AU - Qian, Xuhong

AU - Mao, Ping

AU - Yao, Wei

AU - Guo, Xiangfeng

PY - 2002/4/15

Y1 - 2002/4/15

N2 - A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.

AB - A novel hydroperoxide of benzothioxanthene dicarboximide B4 was synthesized through naphthyl radical-induced aromatic 1,5-hydrogen transfer in an unusual Pschorr cyclization and photooxygenation. It was evaluated as an excellent 'time-resolved' DNA photocleaver with long-wavelength absorption, which can photonick the duplex DNA at a micromolar concentration of 5 μM upon irradiation at 450 nm.

UR - https://www.scopus.com/pages/publications/0037090047

U2 - 10.1016/S0040-4039(02)00442-2

DO - 10.1016/S0040-4039(02)00442-2

M3 - 文章

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SN - 0040-4039

VL - 43

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JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 16

ER -

Synthesis and properties of benzothioxanthene dicarboximide hydroperoxide: An efficient 'time-resolved' DNA photocleaver with long-wavelength

Abstract

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