Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Yu Luo; Feng Xiao; Shijing Qian; Wei Lu; Bo Yang

doi:10.1016/j.ejmech.2010.11.014

Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Yu Luo, Feng Xiao, Shijing Qian, Wei Lu, Bo Yang

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.

Original language	English
Pages (from-to)	417-422
Number of pages	6
Journal	European Journal of Medicinal Chemistry
Volume	46
Issue number	1
DOIs	https://doi.org/10.1016/j.ejmech.2010.11.014
State	Published - Jan 2011

Keywords

A549
Anticancer
SMMC-7721
Synthesis
Thiazolyl benzimidazole

Access to Document

10.1016/j.ejmech.2010.11.014

Cite this

@article{5a2564ba7e0c4851817936f391d295be,

title = "Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives",

abstract = "A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.",

keywords = "A549, Anticancer, SMMC-7721, Synthesis, Thiazolyl benzimidazole",

author = "Yu Luo and Feng Xiao and Shijing Qian and Wei Lu and Bo Yang",

year = "2011",

month = jan,

doi = "10.1016/j.ejmech.2010.11.014",

language = "英语",

volume = "46",

pages = "417--422",

journal = "European Journal of Medicinal Chemistry",

issn = "0223-5234",

publisher = "Elsevier Masson s.r.l.",

number = "1",

}

TY - JOUR

T1 - Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

AU - Luo, Yu

AU - Xiao, Feng

AU - Qian, Shijing

AU - Lu, Wei

AU - Yang, Bo

PY - 2011/1

Y1 - 2011/1

N2 - A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.

AB - A novel kind of thiazolylbenzimidazole derivatives were designed and synthesized and evaluated for their antitumor activity against SMMC-7721 and A549 cell lines. Most compounds showed good antitumor activities, and compound 11b displayed remarkable in vitro anticancer activity comparable to taxol. The preliminary structure-activity relationship of these benzimidazole derivatives was discussed based on the experimental data obtained.

KW - A549

KW - Anticancer

KW - SMMC-7721

KW - Synthesis

KW - Thiazolyl benzimidazole

UR - https://www.scopus.com/pages/publications/78650517443

U2 - 10.1016/j.ejmech.2010.11.014

DO - 10.1016/j.ejmech.2010.11.014

M3 - 文章

C2 - 21115212

AN - SCOPUS:78650517443

SN - 0223-5234

VL - 46

SP - 417

EP - 422

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

IS - 1

ER -

Synthesis and in vitro cytotoxic evaluation of some thiazolylbenzimidazole derivatives

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this