Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

Yan Liu; Yufang Xu; Xuhong Qian; Yi Xiao; Jianwen Liu; Liyun Shen; Junhui Li; Yuanxing Zhang

doi:10.1016/j.bmcl.2005.12.031

Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

Yan Liu
, Yufang Xu^*
, Xuhong Qian
, Yi Xiao
, Jianwen Liu
, Liyun Shen
, Junhui Li
, Yuanxing Zhang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A₂ and A₄ showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

Original language	English
Pages (from-to)	1562-1566
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.bmcl.2005.12.031
State	Published - 15 Mar 2006
Externally published	Yes

Keywords

Evaluation
Fluorescent markers
Hypoxic cells
Solid tumor
Synthesis

Access to Document

10.1016/j.bmcl.2005.12.031

Cite this

@article{a35b78a3ade247d8b49f1b7cad9d0de3,

title = "Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor",

abstract = "Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.",

keywords = "Evaluation, Fluorescent markers, Hypoxic cells, Solid tumor, Synthesis",

author = "Yan Liu and Yufang Xu and Xuhong Qian and Yi Xiao and Jianwen Liu and Liyun Shen and Junhui Li and Yuanxing Zhang",

year = "2006",

month = mar,

day = "15",

doi = "10.1016/j.bmcl.2005.12.031",

language = "英语",

volume = "16",

pages = "1562--1566",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Ltd",

number = "6",

}

TY - JOUR

T1 - Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

AU - Liu, Yan

AU - Xu, Yufang

AU - Qian, Xuhong

AU - Xiao, Yi

AU - Liu, Jianwen

AU - Shen, Liyun

AU - Li, Junhui

AU - Zhang, Yuanxing

PY - 2006/3/15

Y1 - 2006/3/15

N2 - Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

AB - Novel bioreductive and long-wavelength fluorescent markers for hypoxic cells in solid tumor, 9-isocyano-8H-acenaphtho[l,2-b]pyrrol-8-one with the side chain of 2-nitroimidazole, were designed, synthesized, and evaluated in V79 379A Chinese hamster cells in vitro. Compounds A2 and A4 showed good hypoxic-oxic fluorescence differential in vitro (V79 cells) by using fluorescence scan ascent.

KW - Evaluation

KW - Fluorescent markers

KW - Hypoxic cells

KW - Solid tumor

KW - Synthesis

UR - https://www.scopus.com/pages/publications/32044449150

U2 - 10.1016/j.bmcl.2005.12.031

DO - 10.1016/j.bmcl.2005.12.031

M3 - 文章

C2 - 16403630

AN - SCOPUS:32044449150

SN - 0960-894X

VL - 16

SP - 1562

EP - 1566

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 6

ER -

Synthesis and evaluation of novel 8-oxo-8H-cyclopenta[a]acenaphthylene-7- carbonitriles as long-wavelength fluorescent markers for hypoxic cells in solid tumor

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this