Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Yu Luo; Feng Xiao; Shijing Qian; Qiaojun He; Wei Lu; Bo Yang

doi:10.1039/c1md00105a

Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Yu Luo
, Feng Xiao
, Shijing Qian
, Qiaojun He
, Wei Lu^*
, Bo Yang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

Original language	English
Pages (from-to)	1054-1057
Number of pages	4
Journal	MedChemComm
Volume	2
Issue number	11
DOIs	https://doi.org/10.1039/c1md00105a
State	Published - Nov 2011

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title = "Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents",

abstract = "A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.",

author = "Yu Luo and Feng Xiao and Shijing Qian and Qiaojun He and Wei Lu and Bo Yang",

year = "2011",

month = nov,

doi = "10.1039/c1md00105a",

language = "英语",

volume = "2",

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T1 - Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

AU - Luo, Yu

AU - Xiao, Feng

AU - Qian, Shijing

AU - He, Qiaojun

AU - Lu, Wei

AU - Yang, Bo

PY - 2011/11

Y1 - 2011/11

N2 - A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

AB - A series of novel 5-sulfonyl-indolin-2-ones were designed, synthesized, and screened for their antitumor activity on SGC-7901, A549, HCT116, and ECA-109 cell lines. Four compounds with the most potent antitumor activity were further determined as fibroblast growth factor receptor 2 (FGFR2) inhibitors. Among them, compound 2b was further identified to inhibit HUVECs tube formation.

UR - https://www.scopus.com/pages/publications/80455163194

U2 - 10.1039/c1md00105a

DO - 10.1039/c1md00105a

M3 - 文章

AN - SCOPUS:80455163194

SN - 2040-2503

VL - 2

SP - 1054

EP - 1057

JO - MedChemComm

JF - MedChemComm

IS - 11

ER -

Synthesis and evaluation of novel 5-sulfonyl-indolin-2-ones as potent cytotoxic agents

Abstract

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