Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans

Hong Xia Ding; Wei Lu; Chang Xin Zhou; Hai Bo Li; Lei Xiang Yang; Qi Jun Zhang; Xiu Mei Wu; Olivier Baudoin; Jun Chao Cai; Françoise Guéritte; Yu Zhao

Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans

Hong Xia Ding^*
, Wei Lu
, Chang Xin Zhou
, Hai Bo Li
, Lei Xiang Yang
, Qi Jun Zhang
, Xiu Mei Wu
, Olivier Baudoin
, Jun Chao Cai
, Françoise Guéritte
, Yu Zhao

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC ₅₀ values on selected cell lines at μmol/L scale.

Original language	English
Pages (from-to)	1279-1282
Number of pages	4
Journal	Chinese Chemical Letters
Volume	16
Issue number	10
State	Published - Oct 2005
Externally published	Yes

Keywords

1-arylnaphthalene lignans
Cytotoxicity
Isoquinoline derivatives
Synthesis

Cite this

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title = "Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans",

abstract = "Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at μmol/L scale.",

keywords = "1-arylnaphthalene lignans, Cytotoxicity, Isoquinoline derivatives, Synthesis",

author = "Ding, \{Hong Xia\} and Wei Lu and Zhou, \{Chang Xin\} and Li, \{Hai Bo\} and Yang, \{Lei Xiang\} and Zhang, \{Qi Jun\} and Wu, \{Xiu Mei\} and Olivier Baudoin and Cai, \{Jun Chao\} and Fran{\c c}oise Gu{\'e}ritte and Yu Zhao",

year = "2005",

month = oct,

language = "英语",

volume = "16",

pages = "1279--1282",

journal = "Chinese Chemical Letters",

issn = "1001-8417",

publisher = "Elsevier B.V.",

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TY - JOUR

T1 - Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans

AU - Ding, Hong Xia

AU - Lu, Wei

AU - Zhou, Chang Xin

AU - Li, Hai Bo

AU - Yang, Lei Xiang

AU - Zhang, Qi Jun

AU - Wu, Xiu Mei

AU - Baudoin, Olivier

AU - Cai, Jun Chao

AU - Guéritte, Françoise

AU - Zhao, Yu

PY - 2005/10

Y1 - 2005/10

N2 - Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at μmol/L scale.

AB - Two series of novel compounds designed as hybrids of 1-arylnaphthalene lignans with dihydroisoquinolines or isoquinolines were synthesized and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3 and KB. Some of the synthetic compounds exhibited their IC 50 values on selected cell lines at μmol/L scale.

KW - 1-arylnaphthalene lignans

KW - Cytotoxicity

KW - Isoquinoline derivatives

KW - Synthesis

UR - https://www.scopus.com/pages/publications/33745036320

M3 - 文章

AN - SCOPUS:33745036320

SN - 1001-8417

VL - 16

SP - 1279

EP - 1282

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 10

ER -

Synthesis and cytotoxicity evaluation of some isoquinoline derivatives related to 1-arylnaphthalene lignans

Abstract

Keywords

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