Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

Feng Xiao; Yadong Xue; Yu Luo; Bo Zhang; Wei Lu; Bo Yang

doi:10.1016/j.cclet.2008.12.019

Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

Feng Xiao
, Yadong Xue
, Yu Luo^*
, Bo Zhang
, Wei Lu
, Bo Yang

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.

Original language	English
Pages (from-to)	566-568
Number of pages	3
Journal	Chinese Chemical Letters
Volume	20
Issue number	5
DOIs	https://doi.org/10.1016/j.cclet.2008.12.019
State	Published - May 2009

Keywords

Anticancer
Camptothecin
Synthesis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cclet.2008.12.019

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title = "Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives",

abstract = "Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.",

keywords = "Anticancer, Camptothecin, Synthesis",

author = "Feng Xiao and Yadong Xue and Yu Luo and Bo Zhang and Wei Lu and Bo Yang",

year = "2009",

month = may,

doi = "10.1016/j.cclet.2008.12.019",

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volume = "20",

pages = "566--568",

journal = "Chinese Chemical Letters",

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}

TY - JOUR

T1 - Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

AU - Xiao, Feng

AU - Xue, Yadong

AU - Luo, Yu

AU - Zhang, Bo

AU - Lu, Wei

AU - Yang, Bo

PY - 2009/5

Y1 - 2009/5

N2 - Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.

AB - Several 7-alkynyl camptothecin derivatives were prepared via Sonogashira coupling. And anti-tumor activities of these compounds were evaluated against human esophageal cancer cell line (Eca-109), human chronic myeloid leukaemia cell line (K562), bladder cancer cell line (5637) and gastric cell line (SGC7901). Compounds 9a-d and 10a exhibited remarkable in vitro cytotoxic activity, compared with topotecan.

KW - Anticancer

KW - Camptothecin

KW - Synthesis

UR - https://www.scopus.com/pages/publications/62849118422

U2 - 10.1016/j.cclet.2008.12.019

DO - 10.1016/j.cclet.2008.12.019

M3 - 文章

AN - SCOPUS:62849118422

SN - 1001-8417

VL - 20

SP - 566

EP - 568

JO - Chinese Chemical Letters

JF - Chinese Chemical Letters

IS - 5

ER -

Synthesis and cytotoxic activity of 7-alkynyl camptothecin derivatives

Abstract

Keywords

UN SDGs

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