TY - JOUR
T1 - Synthesis and characterization of polyacetals and NMR study on its degradation kinetics
AU - Shu, Jie
AU - Peng, Min
AU - Yu, Jia Hui
AU - Luo, Shu Fang
AU - Yu, Lei
AU - Chen, Qun
PY - 2007/7
Y1 - 2007/7
N2 - With p-TSA as catalyst, four different types of polyacetals (PA1, PA2, PA3, PA4) were synthesized with amino-protected serinol, tri(ethylene glycol) divinyl ether and PEG2000 in different molar ratios. The structure of the resultant polyacetal was characterized with 1H NMR. The degradation process of the copolymers was monitored via 1H NMR in pH = 7.4, 6.5, 5.7 PBS and pH = 4.7, 4.1, 3.8 acetic buffer, respectively. It was found that the degradation reaction in acidic buffer of PA3 obeyed the first order kinetics equation. With decreasing pH values of the buffer solution, the degradation rate constant increases and the half-life decreases.
AB - With p-TSA as catalyst, four different types of polyacetals (PA1, PA2, PA3, PA4) were synthesized with amino-protected serinol, tri(ethylene glycol) divinyl ether and PEG2000 in different molar ratios. The structure of the resultant polyacetal was characterized with 1H NMR. The degradation process of the copolymers was monitored via 1H NMR in pH = 7.4, 6.5, 5.7 PBS and pH = 4.7, 4.1, 3.8 acetic buffer, respectively. It was found that the degradation reaction in acidic buffer of PA3 obeyed the first order kinetics equation. With decreasing pH values of the buffer solution, the degradation rate constant increases and the half-life decreases.
KW - Degradation kinetics
KW - First order kinetics
KW - H NMR
KW - Synthesis of polyacetals
UR - https://www.scopus.com/pages/publications/34547623926
M3 - 文章
AN - SCOPUS:34547623926
SN - 0251-0790
VL - 28
SP - 1398
EP - 1402
JO - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
JF - Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
IS - 7
ER -