Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC

Yi Zhang; Yan Zhang; Guan Wang; Wujuan Chen; Pingang He; Qingjiang Wang

doi:10.1039/c5an02021b

Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC

Yi Zhang
, Yan Zhang
, Guan Wang
, Wujuan Chen
, Pingang He
, Qingjiang Wang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A novel Congo red (CR) derivatized silica stationary phase was prepared and packed into a fused silica capillary tube for nano-flow HPLC. A variety of analytes including poly-aromatic hydrocarbons, parabens, acids, sulfonamides, bases, and nucleosides were successfully separated using the CR. In comparison with commercial ODS columns, this new stationary phase has a different separation mechanism (hydrophobically-assisted ion-exchange), which was evident in the separation of benzoic acid derivatives and sulfonamides. The successful application of CR-bonded silica stationary phase in the HILIC and PALC modes demonstrates the effectiveness of this potential chromatographic material in nano flow HPLC.

Original language	English
Pages (from-to)	1083-1090
Number of pages	8
Journal	Analyst
Volume	141
Issue number	3
DOIs	https://doi.org/10.1039/c5an02021b
State	Published - 7 Feb 2016

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title = "Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC",

abstract = "A novel Congo red (CR) derivatized silica stationary phase was prepared and packed into a fused silica capillary tube for nano-flow HPLC. A variety of analytes including poly-aromatic hydrocarbons, parabens, acids, sulfonamides, bases, and nucleosides were successfully separated using the CR. In comparison with commercial ODS columns, this new stationary phase has a different separation mechanism (hydrophobically-assisted ion-exchange), which was evident in the separation of benzoic acid derivatives and sulfonamides. The successful application of CR-bonded silica stationary phase in the HILIC and PALC modes demonstrates the effectiveness of this potential chromatographic material in nano flow HPLC.",

author = "Yi Zhang and Yan Zhang and Guan Wang and Wujuan Chen and Pingang He and Qingjiang Wang",

note = "Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2016.",

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T2 - Congo red derivatized silica in nano-flow HPLC

AU - Zhang, Yi

AU - Zhang, Yan

AU - Wang, Guan

AU - Chen, Wujuan

AU - He, Pingang

AU - Wang, Qingjiang

PY - 2016/2/7

Y1 - 2016/2/7

N2 - A novel Congo red (CR) derivatized silica stationary phase was prepared and packed into a fused silica capillary tube for nano-flow HPLC. A variety of analytes including poly-aromatic hydrocarbons, parabens, acids, sulfonamides, bases, and nucleosides were successfully separated using the CR. In comparison with commercial ODS columns, this new stationary phase has a different separation mechanism (hydrophobically-assisted ion-exchange), which was evident in the separation of benzoic acid derivatives and sulfonamides. The successful application of CR-bonded silica stationary phase in the HILIC and PALC modes demonstrates the effectiveness of this potential chromatographic material in nano flow HPLC.

AB - A novel Congo red (CR) derivatized silica stationary phase was prepared and packed into a fused silica capillary tube for nano-flow HPLC. A variety of analytes including poly-aromatic hydrocarbons, parabens, acids, sulfonamides, bases, and nucleosides were successfully separated using the CR. In comparison with commercial ODS columns, this new stationary phase has a different separation mechanism (hydrophobically-assisted ion-exchange), which was evident in the separation of benzoic acid derivatives and sulfonamides. The successful application of CR-bonded silica stationary phase in the HILIC and PALC modes demonstrates the effectiveness of this potential chromatographic material in nano flow HPLC.

UR - https://www.scopus.com/pages/publications/84956710831

U2 - 10.1039/c5an02021b

DO - 10.1039/c5an02021b

M3 - 文章

C2 - 26646316

AN - SCOPUS:84956710831

SN - 0003-2654

VL - 141

SP - 1083

EP - 1090

JO - Analyst

JF - Analyst

IS - 3

ER -

Synthesis and characterization of a multimode stationary phase: Congo red derivatized silica in nano-flow HPLC

Abstract

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