Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines

Hongxia Ding; Wei Lu; Haibo Li; Leixiang Yang; Qijun Zhang; Changxin Zhou; Xiumei Wu; Olivier Baudoin; Junchao Cai; Françoise Guéritte; Yu Zhao

doi:10.1002/cbdv.200590092

Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines

Hongxia Ding
, Wei Lu
, Haibo Li
, Leixiang Yang
, Qijun Zhang
, Changxin Zhou
, Xiumei Wu
, Olivier Baudoin
, Junchao Cai
, Françoise Guéritte
, Yu Zhao^*

^*Corresponding author for this work

Zhejiang University
CAS - Shanghai Institute of Materia Medica
Zhejiang Hisun Naturelite Pharmaceutical R and D Co. Ltd.
CNRS

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC₅₀ values on selected cell lines at 10^-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.

Original language	English
Pages (from-to)	1217-1231
Number of pages	15
Journal	Chemistry and Biodiversity
Volume	2
Issue number	9
DOIs	https://doi.org/10.1002/cbdv.200590092
State	Published - 2005
Externally published	Yes

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title = "Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines",

abstract = "Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.",

author = "Hongxia Ding and Wei Lu and Haibo Li and Leixiang Yang and Qijun Zhang and Changxin Zhou and Xiumei Wu and Olivier Baudoin and Junchao Cai and Fran{\c c}oise Gu{\'e}ritte and Yu Zhao",

year = "2005",

doi = "10.1002/cbdv.200590092",

language = "英语",

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T1 - Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines

AU - Ding, Hongxia

AU - Lu, Wei

AU - Li, Haibo

AU - Yang, Leixiang

AU - Zhang, Qijun

AU - Zhou, Changxin

AU - Wu, Xiumei

AU - Baudoin, Olivier

AU - Cai, Junchao

AU - Guéritte, Françoise

AU - Zhao, Yu

PY - 2005

Y1 - 2005

N2 - Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.

AB - Novel compounds designed as hybrids of 1-arylnaphthalene lignans with isoquinoline alkaloids were prepared and evaluated for their cytotoxicities on human tumor cell lines, such as A549, Hela, PC-3, CNE, BEL-7404, and KB. Some of the synthetic compounds exhibited their IC50 values on selected cell lines at 10-6 m scale. The preliminary CoMFA molecular-modelling studies of these synthetic analogues were also performed.

UR - https://www.scopus.com/pages/publications/26044436557

U2 - 10.1002/cbdv.200590092

DO - 10.1002/cbdv.200590092

M3 - 文章

C2 - 17193204

AN - SCOPUS:26044436557

SN - 1612-1872

VL - 2

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EP - 1231

JO - Chemistry and Biodiversity

JF - Chemistry and Biodiversity

IS - 9

ER -

Synthesis and biological evaluation of novel compounds related to 1-arylnaphthalene lignans and isoquinolines

Abstract

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