Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

Wei Gang Huang; Ying Yan Jiang; Qian Li; Jia Li; Jing Ya Li; Wei Lu; Jun Chao Cai

doi:10.1016/j.tet.2004.12.033

Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

Wei Gang Huang, Ying Yan Jiang, Qian Li, Jia Li, Jing Ya Li, Wei Lu, Jun Chao Cai

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

(±)-Cryptotanshinone and its simplified analogues were synthesized via SmI₂ promoted radical cyclization to construct the furan ring. Analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.

Original language	English
Pages (from-to)	1863-1870
Number of pages	8
Journal	Tetrahedron
Volume	61
Issue number	7
DOIs	https://doi.org/10.1016/j.tet.2004.12.033
State	Published - 14 Feb 2005
Externally published	Yes

Keywords

Analogues
Antitumor
CDC25 Inhibitor
Cryptotanshinone

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tet.2004.12.033

Cite this

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title = "Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors",

abstract = "(±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.",

keywords = "Analogues, Antitumor, CDC25 Inhibitor, Cryptotanshinone",

author = "Huang, \{Wei Gang\} and Jiang, \{Ying Yan\} and Qian Li and Jia Li and Li, \{Jing Ya\} and Wei Lu and Cai, \{Jun Chao\}",

year = "2005",

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day = "14",

doi = "10.1016/j.tet.2004.12.033",

language = "英语",

volume = "61",

pages = "1863--1870",

journal = "Tetrahedron",

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number = "7",

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TY - JOUR

T1 - Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

AU - Huang, Wei Gang

AU - Jiang, Ying Yan

AU - Li, Qian

AU - Li, Jia

AU - Li, Jing Ya

AU - Lu, Wei

AU - Cai, Jun Chao

PY - 2005/2/14

Y1 - 2005/2/14

N2 - (±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.

AB - (±)-Cryptotanshinone and its simplified analogues were synthesized via SmI2 promoted radical cyclization to construct the furan ring. Analogues 18 and 26 were identified as effective inhibitors of dual specificity protein phosphatase CDC25B which is a key enzyme for cell cycle progression, and they also inhibited growth in A-549 human lung cancer cell line.

KW - Analogues

KW - Antitumor

KW - CDC25 Inhibitor

KW - Cryptotanshinone

UR - https://www.scopus.com/pages/publications/12944325299

U2 - 10.1016/j.tet.2004.12.033

DO - 10.1016/j.tet.2004.12.033

M3 - 文章

AN - SCOPUS:12944325299

SN - 0040-4020

VL - 61

SP - 1863

EP - 1870

JO - Tetrahedron

JF - Tetrahedron

IS - 7

ER -

Synthesis and biological evaluation of (±)-cryptotanshinone and its simplified analogues as potent CDC25 inhibitors

Abstract

Keywords

UN SDGs

Access to Document

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