Synthesis and antitumor activity of tanshinone analogues

Haji Akber Aisa; Wei Lu; Jun Chao Cai

doi:10.1002/cjoc.20030210703

Synthesis and antitumor activity of tanshinone analogues

Haji Akber Aisa^*
, Wei Lu
, Jun Chao Cai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

Original language	English
Pages (from-to)	720-722
Number of pages	3
Journal	Chinese Journal of Chemistry
Volume	21
Issue number	7
DOIs	https://doi.org/10.1002/cjoc.20030210703
State	Published - Jul 2003
Externally published	Yes

Keywords

Analogues
Synthesis
Tanshinone

Access to Document

10.1002/cjoc.20030210703

Cite this

@article{53581cbef8764a39910242c138790d3f,

title = "Synthesis and antitumor activity of tanshinone analogues",

abstract = "8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.",

keywords = "Analogues, Synthesis, Tanshinone",

author = "Aisa, \{Haji Akber\} and Wei Lu and Cai, \{Jun Chao\}",

year = "2003",

month = jul,

doi = "10.1002/cjoc.20030210703",

language = "英语",

volume = "21",

pages = "720--722",

journal = "Chinese Journal of Chemistry",

issn = "1001-604X",

publisher = "John Wiley and Sons Inc",

number = "7",

}

TY - JOUR

T1 - Synthesis and antitumor activity of tanshinone analogues

AU - Aisa, Haji Akber

AU - Lu, Wei

AU - Cai, Jun Chao

PY - 2003/7

Y1 - 2003/7

N2 - 8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

AB - 8,8-Dimethyl-5,6,7,8-tetrahydrophenanthrene-3,4-dione (3) and 8,8-dimethyl-2-(1-hydroxy ethyl)-5,6,7,8-tetrahydrophenanthrene-3,4-dione (4), two analogues of the antitumor active tanshinone, were synthesized from anisole. The synthesized compounds 3 and 4 were shown to be highly active against leukemia P-388 cell line as assayed by in vitro MTT method.

KW - Analogues

KW - Synthesis

KW - Tanshinone

UR - https://www.scopus.com/pages/publications/33748042967

U2 - 10.1002/cjoc.20030210703

DO - 10.1002/cjoc.20030210703

M3 - 文章

AN - SCOPUS:33748042967

SN - 1001-604X

VL - 21

SP - 720

EP - 722

JO - Chinese Journal of Chemistry

JF - Chinese Journal of Chemistry

IS - 7

ER -

Synthesis and antitumor activity of tanshinone analogues

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this