TY - JOUR
T1 - Syntheses and characterization of 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups
AU - Zhang, Rong
AU - Qian, Xuhong
AU - Li, Zhong
PY - 1999/1/4
Y1 - 1999/1/4
N2 - In order to develop an effective synthetic route to 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups, a novel intermediate 2-amino-5-[4-(2′,2′,2′-trifluoroethoxy)-phenyl]-1,3,4- oxadiazole was prepared and its structure was confirmed by mass spectrometry and 1H NMR spectroscopy. The chlorine atom was not substituted by trifluoroethoxy groups, when syntheses of the intermediate by direct trifluoroethoxylation of 2-amino-5-(4-chlorophenyl)-1,3,4-oxadiazole was tried. The resulting product was characterized as N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-4-chlorobenzamide. A possible reaction mechanism is suggested.
AB - In order to develop an effective synthetic route to 2-amino-5-aryl-1,3,4-oxadiazoles containing trifluoroethoxy groups, a novel intermediate 2-amino-5-[4-(2′,2′,2′-trifluoroethoxy)-phenyl]-1,3,4- oxadiazole was prepared and its structure was confirmed by mass spectrometry and 1H NMR spectroscopy. The chlorine atom was not substituted by trifluoroethoxy groups, when syntheses of the intermediate by direct trifluoroethoxylation of 2-amino-5-(4-chlorophenyl)-1,3,4-oxadiazole was tried. The resulting product was characterized as N-[5-(4-chlorophenyl)-1,3,4-oxadiazol-2-yl]-4-chlorobenzamide. A possible reaction mechanism is suggested.
KW - Characterization
KW - Mechanism
KW - Oxadiazole
KW - Synthesis
KW - Trifluoroethoxylation
UR - https://www.scopus.com/pages/publications/0347180326
U2 - 10.1016/S0022-1139(98)00269-3
DO - 10.1016/S0022-1139(98)00269-3
M3 - 文章
AN - SCOPUS:0347180326
SN - 0022-1139
VL - 93
SP - 39
EP - 43
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 1
ER -