Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

Jinlou Gu; Shasha Su; Yongsheng Li; Qianjun He; Jiaying Zhong; Jianlin Shi

doi:10.1021/jz101483u

Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

Jinlou Gu^*
, Shasha Su
, Yongsheng Li
, Qianjun He
, Jiaying Zhong
, Jianlin Shi

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

80 Scopus citations

Abstract

High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

Original language	English
Pages (from-to)	3446-3450
Number of pages	5
Journal	Journal of Physical Chemistry Letters
Volume	1
Issue number	24
DOIs	https://doi.org/10.1021/jz101483u
State	Published - 16 Dec 2010
Externally published	Yes

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10.1021/jz101483u

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@article{0b3809f4225b46d7a10dcc2f2c53a249,

title = "Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles",

abstract = "High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.",

author = "Jinlou Gu and Shasha Su and Yongsheng Li and Qianjun He and Jiaying Zhong and Jianlin Shi",

year = "2010",

month = dec,

day = "16",

doi = "10.1021/jz101483u",

language = "英语",

volume = "1",

pages = "3446--3450",

journal = "Journal of Physical Chemistry Letters",

issn = "1948-7185",

publisher = "American Chemical Society",

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}

TY - JOUR

T1 - Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

AU - Gu, Jinlou

AU - Su, Shasha

AU - Li, Yongsheng

AU - He, Qianjun

AU - Zhong, Jiaying

AU - Shi, Jianlin

PY - 2010/12/16

Y1 - 2010/12/16

N2 - High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

AB - High-density carboxyl groups have been successfully grafted onto the pore surface of mesoporous nanocarriers which served to complex with platinum atoms in cisplatin, leading to much increased drug loading efficiency, distinctly prolonged and pH-responsive cisplatin release, and greatly enhanced growth inhibition effect against MCF-7 and HeLa cancer cell lines.

UR - https://www.scopus.com/pages/publications/78650326921

U2 - 10.1021/jz101483u

DO - 10.1021/jz101483u

M3 - 文章

AN - SCOPUS:78650326921

SN - 1948-7185

VL - 1

SP - 3446

EP - 3450

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

IS - 24

ER -

Surface modification-Complexation strategy for cisplatin loading in mesoporous nanoparticles

Abstract

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