Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates

Yanyan Liao; Ming Wang; Xuefeng Jiang

doi:10.1016/j.cbpa.2023.102336

Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates

Yanyan Liao
, Ming Wang^*
, Xuefeng Jiang^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University
CAS - Shanghai Institute of Organic Chemistry
Nankai University

Research output: Contribution to journal › Review article › peer-review

27 Scopus citations

Abstract

Peptides act as biological mediators and play a key role of various physiological activities. Sulfur-containing peptides are widely used in natural products and drug molecules due to their unique biological activity and chemical reactivity of sulfur. Disulfides, thioethers, and thioamides are the most common motifs of sulfur-containing peptides, and they have been extensively studied and developed for synthetic methodology as well as pharmaceutical applications. This review focuses on the illustration of these three motifs in natural products and drugs, as well as the recent advancements in the synthesis of the corresponding core scaffolds.

Original language	English
Article number	102336
Journal	Current Opinion in Chemical Biology
Volume	75
DOIs	https://doi.org/10.1016/j.cbpa.2023.102336
State	Published - Aug 2023

Keywords

Disulfide
Medicinal chemistry
Sulfur-containing peptides
Thioamide
Thioether

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10.1016/j.cbpa.2023.102336

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title = "Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates",

abstract = "Peptides act as biological mediators and play a key role of various physiological activities. Sulfur-containing peptides are widely used in natural products and drug molecules due to their unique biological activity and chemical reactivity of sulfur. Disulfides, thioethers, and thioamides are the most common motifs of sulfur-containing peptides, and they have been extensively studied and developed for synthetic methodology as well as pharmaceutical applications. This review focuses on the illustration of these three motifs in natural products and drugs, as well as the recent advancements in the synthesis of the corresponding core scaffolds.",

keywords = "Disulfide, Medicinal chemistry, Sulfur-containing peptides, Thioamide, Thioether",

author = "Yanyan Liao and Ming Wang and Xuefeng Jiang",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Ltd",

year = "2023",

month = aug,

doi = "10.1016/j.cbpa.2023.102336",

language = "英语",

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TY - JOUR

T1 - Sulfur-containing peptides

T2 - Synthesis and application in the discovery of potential drug candidates

AU - Liao, Yanyan

AU - Wang, Ming

AU - Jiang, Xuefeng

PY - 2023/8

Y1 - 2023/8

N2 - Peptides act as biological mediators and play a key role of various physiological activities. Sulfur-containing peptides are widely used in natural products and drug molecules due to their unique biological activity and chemical reactivity of sulfur. Disulfides, thioethers, and thioamides are the most common motifs of sulfur-containing peptides, and they have been extensively studied and developed for synthetic methodology as well as pharmaceutical applications. This review focuses on the illustration of these three motifs in natural products and drugs, as well as the recent advancements in the synthesis of the corresponding core scaffolds.

AB - Peptides act as biological mediators and play a key role of various physiological activities. Sulfur-containing peptides are widely used in natural products and drug molecules due to their unique biological activity and chemical reactivity of sulfur. Disulfides, thioethers, and thioamides are the most common motifs of sulfur-containing peptides, and they have been extensively studied and developed for synthetic methodology as well as pharmaceutical applications. This review focuses on the illustration of these three motifs in natural products and drugs, as well as the recent advancements in the synthesis of the corresponding core scaffolds.

KW - Disulfide

KW - Medicinal chemistry

KW - Sulfur-containing peptides

KW - Thioamide

KW - Thioether

UR - https://www.scopus.com/pages/publications/85161057604

U2 - 10.1016/j.cbpa.2023.102336

DO - 10.1016/j.cbpa.2023.102336

M3 - 文献综述

C2 - 37269675

AN - SCOPUS:85161057604

SN - 1367-5931

VL - 75

JO - Current Opinion in Chemical Biology

JF - Current Opinion in Chemical Biology

M1 - 102336

ER -

Sulfur-containing peptides: Synthesis and application in the discovery of potential drug candidates

Abstract

Keywords

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