Study on the immunogenicity of HIV-1 gag vaccine

Wen Zheng Jiang; Ning Yi Jin; Zi Jian Li; Li Shu Zhang

Study on the immunogenicity of HIV-1 gag vaccine

Wen Zheng Jiang^*
, Ning Yi Jin
, Zi Jian Li
, Li Shu Zhang

^*Corresponding author for this work

Quartermaster University of PLA

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

AIM: To detect the immunogenicity of HIV-1 gag DNA vaccine. METHODS: The serum antibody titers of the immunized mice were detected by ELISA. The numbers of spleen's CD4(+) and CD8(+) T cells were analyzed by the fluorescent antibody staining and the cytotoxic activity was determined by lactate dehydrogenase (LDH) release assay. RESULTS: The titers of the serum antibodies and the numbers and cytotoxic activity of spleen's T lymphocyte subsets had significant differences (P<0.05 and P<0.01, respectively) between pVAXGAG and pVAX1 vaccinated groups. CONCLUSION: HIV-1 DNA vaccine plasmid pVAXGAG could elicit both the specific humoral and cellular immunities in BALB/c mice.

Original language	English
Pages (from-to)	272-273
Number of pages	2
Journal	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology
Volume	20
Issue number	3
State	Published - May 2004
Externally published	Yes

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SDG 3 Good Health and Well-being

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title = "Study on the immunogenicity of HIV-1 gag vaccine",

abstract = "AIM: To detect the immunogenicity of HIV-1 gag DNA vaccine. METHODS: The serum antibody titers of the immunized mice were detected by ELISA. The numbers of spleen's CD4(+) and CD8(+) T cells were analyzed by the fluorescent antibody staining and the cytotoxic activity was determined by lactate dehydrogenase (LDH) release assay. RESULTS: The titers of the serum antibodies and the numbers and cytotoxic activity of spleen's T lymphocyte subsets had significant differences (P<0.05 and P<0.01, respectively) between pVAXGAG and pVAX1 vaccinated groups. CONCLUSION: HIV-1 DNA vaccine plasmid pVAXGAG could elicit both the specific humoral and cellular immunities in BALB/c mice.",

author = "Jiang, \{Wen Zheng\} and Jin, \{Ning Yi\} and Li, \{Zi Jian\} and Zhang, \{Li Shu\}",

year = "2004",

month = may,

language = "英语",

volume = "20",

pages = "272--273",

journal = "Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology",

issn = "1007-8738",

publisher = "Fourth Military Medical University",

number = "3",

}

TY - JOUR

T1 - Study on the immunogenicity of HIV-1 gag vaccine

AU - Jiang, Wen Zheng

AU - Jin, Ning Yi

AU - Li, Zi Jian

AU - Zhang, Li Shu

PY - 2004/5

Y1 - 2004/5

N2 - AIM: To detect the immunogenicity of HIV-1 gag DNA vaccine. METHODS: The serum antibody titers of the immunized mice were detected by ELISA. The numbers of spleen's CD4(+) and CD8(+) T cells were analyzed by the fluorescent antibody staining and the cytotoxic activity was determined by lactate dehydrogenase (LDH) release assay. RESULTS: The titers of the serum antibodies and the numbers and cytotoxic activity of spleen's T lymphocyte subsets had significant differences (P<0.05 and P<0.01, respectively) between pVAXGAG and pVAX1 vaccinated groups. CONCLUSION: HIV-1 DNA vaccine plasmid pVAXGAG could elicit both the specific humoral and cellular immunities in BALB/c mice.

AB - AIM: To detect the immunogenicity of HIV-1 gag DNA vaccine. METHODS: The serum antibody titers of the immunized mice were detected by ELISA. The numbers of spleen's CD4(+) and CD8(+) T cells were analyzed by the fluorescent antibody staining and the cytotoxic activity was determined by lactate dehydrogenase (LDH) release assay. RESULTS: The titers of the serum antibodies and the numbers and cytotoxic activity of spleen's T lymphocyte subsets had significant differences (P<0.05 and P<0.01, respectively) between pVAXGAG and pVAX1 vaccinated groups. CONCLUSION: HIV-1 DNA vaccine plasmid pVAXGAG could elicit both the specific humoral and cellular immunities in BALB/c mice.

UR - https://www.scopus.com/pages/publications/16544377236

M3 - 文章

C2 - 15193215

AN - SCOPUS:16544377236

SN - 1007-8738

VL - 20

SP - 272

EP - 273

JO - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

JF - Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology

IS - 3

ER -

Study on the immunogenicity of HIV-1 gag vaccine

Abstract

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