Strategies for the total synthesis of the furanosteroids: Wortmannin and viridin

Dongsheng Xue; Haibing He; Shuanhu Gao

doi:10.1246/cl.200841

Strategies for the total synthesis of the furanosteroids: Wortmannin and viridin

Dongsheng Xue
, Haibing He
, Shuanhu Gao^*

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Review article › peer-review

4 Scopus citations

Abstract

Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin.

Original language	English
Pages (from-to)	497-502
Number of pages	6
Journal	Chemistry Letters
Volume	50
Issue number	3
DOIs	https://doi.org/10.1246/cl.200841
State	Published - Mar 2021

Keywords

Total synthesis
Viridin
Wortmannin

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10.1246/cl.200841

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title = "Strategies for the total synthesis of the furanosteroids: Wortmannin and viridin",

abstract = "Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin.",

keywords = "Total synthesis, Viridin, Wortmannin",

author = "Dongsheng Xue and Haibing He and Shuanhu Gao",

note = "Publisher Copyright: {\textcopyright} 2021 The Chemical Society of Japan",

year = "2021",

month = mar,

doi = "10.1246/cl.200841",

language = "英语",

volume = "50",

pages = "497--502",

journal = "Chemistry Letters",

issn = "0366-7022",

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TY - JOUR

T1 - Strategies for the total synthesis of the furanosteroids

T2 - Wortmannin and viridin

AU - Xue, Dongsheng

AU - He, Haibing

AU - Gao, Shuanhu

PY - 2021/3

Y1 - 2021/3

N2 - Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin.

AB - Furanosteroids are polycyclic natural products isolated from fungus, which consist of wortmannin and viridin containing a [5,6,6,6]-tetracyclic skeleton in addition to a furan ring. They inhibit phosphoinositide 3-kinases, suggesting drug potential. This highlight review describes strategies that have been reported for building the tetracyclic ring skeleton and the all-carbon quaternary center in order to achieve total syntheses of wortmannin and viridin.

KW - Total synthesis

KW - Viridin

KW - Wortmannin

UR - https://www.scopus.com/pages/publications/85104947962

U2 - 10.1246/cl.200841

DO - 10.1246/cl.200841

M3 - 文献综述

AN - SCOPUS:85104947962

SN - 0366-7022

VL - 50

SP - 497

EP - 502

JO - Chemistry Letters

JF - Chemistry Letters

IS - 3

ER -

Strategies for the total synthesis of the furanosteroids: Wortmannin and viridin

Abstract

Keywords

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