Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies

Xueyan Feng; Yiyun Cheng; Qinglin Wu; Jiahai Zhang; Tongwen Xu

doi:10.1021/jp2003613

Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies

Xueyan Feng
, Yiyun Cheng^*
, Qinglin Wu
, Jiahai Zhang
, Tongwen Xu

^*Corresponding author for this work

School of Life Sciences

University of Science and Technology of China
East China Normal University

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and ¹H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.

Original language	English
Pages (from-to)	3777-3783
Number of pages	7
Journal	Journal of Physical Chemistry B
Volume	115
Issue number	14
DOIs	https://doi.org/10.1021/jp2003613
State	Published - 14 Apr 2011

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title = "Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies",

abstract = "Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and 1H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.",

author = "Xueyan Feng and Yiyun Cheng and Qinglin Wu and Jiahai Zhang and Tongwen Xu",

year = "2011",

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T1 - Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies

AU - Feng, Xueyan

AU - Cheng, Yiyun

AU - Wu, Qinglin

AU - Zhang, Jiahai

AU - Xu, Tongwen

PY - 2011/4/14

Y1 - 2011/4/14

N2 - Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and 1H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.

AB - Stimuli response behaviors of cystamine-core dendrimer in the presence of several reducing agents including vitamin C, sodium bisulfite, and dl-Dithiothreitol are described. A competitive redox cleavage and supramolecular aggregate formation model is proposed based on PFG NMR and 1H NMR titration experiments. Furthermore, reduction-responsive release of guest molecules from interior pockets of the cystamine-core dendrimer is confirmed by NOE studies. The results suggest that cystamine-core dendrimer is a versatile scaffold or precursor in the design of reduction-sensitive polymeric nanocapsules for biomedical purposes.

UR - https://www.scopus.com/pages/publications/79953792103

U2 - 10.1021/jp2003613

DO - 10.1021/jp2003613

M3 - 文章

AN - SCOPUS:79953792103

SN - 1520-6106

VL - 115

SP - 3777

EP - 3783

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

IS - 14

ER -

Stimuli response of cystamine-core dendrimer revealed by diffusion and NOE NMR studies

Abstract

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