Stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric michael addition

Xuan Zhang; Wei Yuan; Yu Luo; Qing Qing Huang; Wei Lu

doi:10.3987/COM-11-12366

Stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric michael addition

Xuan Zhang, Wei Yuan, Yu Luo, Qing Qing Huang, Wei Lu

School of Chemistry and Molecular Engineering

East China Normal University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Highly enantioselective asymmetric Michael addition was used to synthesize ramelteon and its analogue. The asymmetric strategy provides an efficient approach for the medicinal modification of ramelteon with high ee value.

Original language	English
Pages (from-to)	73-84
Number of pages	12
Journal	Heterocycles
Volume	85
Issue number	1
DOIs	https://doi.org/10.3987/COM-11-12366
State	Published - 2012

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title = "Stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric michael addition",

abstract = "Highly enantioselective asymmetric Michael addition was used to synthesize ramelteon and its analogue. The asymmetric strategy provides an efficient approach for the medicinal modification of ramelteon with high ee value.",

author = "Xuan Zhang and Wei Yuan and Yu Luo and Huang, \{Qing Qing\} and Wei Lu",

year = "2012",

doi = "10.3987/COM-11-12366",

language = "英语",

volume = "85",

pages = "73--84",

journal = "Heterocycles",

issn = "0385-5414",

publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric michael addition

AU - Zhang, Xuan

AU - Yuan, Wei

AU - Luo, Yu

AU - Huang, Qing Qing

AU - Lu, Wei

PY - 2012

Y1 - 2012

N2 - Highly enantioselective asymmetric Michael addition was used to synthesize ramelteon and its analogue. The asymmetric strategy provides an efficient approach for the medicinal modification of ramelteon with high ee value.

AB - Highly enantioselective asymmetric Michael addition was used to synthesize ramelteon and its analogue. The asymmetric strategy provides an efficient approach for the medicinal modification of ramelteon with high ee value.

UR - https://www.scopus.com/pages/publications/84855385407

U2 - 10.3987/COM-11-12366

DO - 10.3987/COM-11-12366

M3 - 文章

AN - SCOPUS:84855385407

SN - 0385-5414

VL - 85

SP - 73

EP - 84

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

Stereoselective synthesis of melatonin receptor agonist ramelteon via asymmetric michael addition

Abstract

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