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Solvent-free Ugi four-component condensation: application to synthesis of philanthotoxins-12 analogues

  • Nianjin Liu
  • , Song Cao*
  • , Jingjing Wu
  • , Jinlong Yu
  • , Li Shen
  • , Xin Feng
  • , Xuhong Qian
  • *Corresponding author for this work
  • East China University of Science and Technology

Research output: Contribution to journalArticlepeer-review

Abstract

Philanthotoxins-12 analogues was synthesized by a highly convergent approach, utilizing an efficient, simple, and convenient one-pot Ugi four-component solvent-free method as key step, followed by removal of the protecting groups in the presence of trifluoroacetic acid.

Original languageEnglish
Pages (from-to)3966-3974
Number of pages9
JournalTetrahedron
Volume64
Issue number18
DOIs
StatePublished - 28 Apr 2008
Externally publishedYes

Keywords

  • Philanthotoxins analogues
  • Solvent-free
  • Ugi 4CR
  • α-Acylamino amide

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