Abstract
The aqueous solubility of non-steroidal anti-inflammatory drugs (NSAIDs) Ketoprofen, Ibuprofen, Diflunisal and Naproxen were measured in the presence of the Tween series surfactants at 37°C. Results showed that the solubility of NSAIDs in the Tween solutions was approximately proportional to Tween concentration; the ability of Tween series surfactants to solubilize NSAIDs in the present study was Tween-80 > Tween-60 > Tween-40 > Tween-20; the order of increased solubility of NSAIDs in Tween series surfactants at a constant Tween series and concentration was Ibuprofen > Ketoprofen > Diflunisal > Naproxen. Under suitable conditions Tween series surfactants can be highly effective used to enhance the solubility of NSAIDs.
| Original language | English |
|---|---|
| Pages (from-to) | 249-256 |
| Number of pages | 8 |
| Journal | Physics and Chemistry of Liquids |
| Volume | 44 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jun 2006 |
| Externally published | Yes |
Keywords
- Absorption
- Micelle
- NSAIDs
- Nanocapsules
- Solubility
- Tween series surfactants
- UV/Vis spectroscopy