Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy

Jie Zhu; Huixiang Wang; Lei Liao; Lingzhi Zhao; Liang Zhou; Meihua Yu; Yunhua Wang; Baohong Liu; Chengzhong Yu

doi:10.1002/asia.201100064

Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy

Jie Zhu
, Huixiang Wang
, Lei Liao
, Lingzhi Zhao
, Liang Zhou
, Meihua Yu
, Yunhua Wang
, Baohong Liu^*
, Chengzhong Yu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl₂ (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl₂ being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl₂ at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.

Original language	English
Pages (from-to)	2332-2338
Number of pages	7
Journal	Chemistry - An Asian Journal
Volume	6
Issue number	9
DOIs	https://doi.org/10.1002/asia.201100064
State	Published - 5 Sep 2011
Externally published	Yes

Keywords

mesoporous
photodynamic therapy
photosensitizers
silica nanoparticles

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/asia.201100064

Cite this

@article{3c69ff1e4c4a4653af4adb2215d2d861,

title = "Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy",

abstract = "Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6 \% in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.",

keywords = "mesoporous, photodynamic therapy, photosensitizers, silica nanoparticles",

author = "Jie Zhu and Huixiang Wang and Lei Liao and Lingzhi Zhao and Liang Zhou and Meihua Yu and Yunhua Wang and Baohong Liu and Chengzhong Yu",

year = "2011",

month = sep,

day = "5",

doi = "10.1002/asia.201100064",

language = "英语",

volume = "6",

pages = "2332--2338",

journal = "Chemistry - An Asian Journal",

issn = "1861-4728",

publisher = "John Wiley and Sons Ltd",

number = "9",

}

TY - JOUR

T1 - Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy

AU - Zhu, Jie

AU - Wang, Huixiang

AU - Liao, Lei

AU - Zhao, Lingzhi

AU - Zhou, Liang

AU - Yu, Meihua

AU - Wang, Yunhua

AU - Liu, Baohong

AU - Yu, Chengzhong

PY - 2011/9/5

Y1 - 2011/9/5

N2 - Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.

AB - Small mesoporous silica nanoparticles (MSNs; ca. 37 nm in diameter) have a high loading capacity for a hydrophobic photosensitizer, SiPcCl2 (82.6 % in weight), and excellent endocytosis properties. As a result, the amount of SiPcCl2 being delivered to cancer cells is increased by approximately two orders of magnitude compared to pure SiPcCl2 at the same dosage, and the photodynamic therapy (PDT) efficiency is enhanced by over fourfold. Our method can be widely used to increase the dosage of hydrophobic anti-cancer drugs in cancer cells and therefore increase the cytotoxicity of the drugs.

KW - mesoporous

KW - photodynamic therapy

KW - photosensitizers

KW - silica nanoparticles

UR - https://www.scopus.com/pages/publications/80051721582

U2 - 10.1002/asia.201100064

DO - 10.1002/asia.201100064

M3 - 文章

C2 - 21744503

AN - SCOPUS:80051721582

SN - 1861-4728

VL - 6

SP - 2332

EP - 2338

JO - Chemistry - An Asian Journal

JF - Chemistry - An Asian Journal

IS - 9

ER -

Small mesoporous silica nanoparticles as carriers for enhanced photodynamic therapy

Abstract

Keywords

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this