Skin-on-a-Chip Coupled with a Rapid Inflammation Detection System for Cosmetic Ingredient Screening

The skin is the largest organ in the human body, and the physical and chemical factors from which human skin suffers make the human body prone to allergic and inflammatory reactions. The animal testing that has been used to evaluate the skin toxicity of drug and cosmetic ingredients in the past has been faced with increasing calls for its abolition. Therefore, there is an increasing demand for in vitro testing methods that can evaluate their efficacy, such as for anti-inflammation, etc. In this paper, a simple skin-on-a-chip coupled with a rapid multiplex immunodetection system for inflammatory cytokine detection is proposed. This platform can be used to quickly screen cosmetic ingredients and drugs.