Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Min Zhu; Yanyan Yu; Junfeng Zhu; Yao Zhou; Gaoxing Su; Hongyan Zhu; Yong Chen; Mingkai Liu

doi:10.1039/d0cc03425h

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Min Zhu, Yanyan Yu^*, Junfeng Zhu, Yao Zhou, Gaoxing Su, Hongyan Zhu, Yong Chen, Mingkai Liu

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

Original language	English
Pages (from-to)	8599-8602
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	61
DOIs	https://doi.org/10.1039/d0cc03425h
State	Published - 7 Aug 2020
Externally published	Yes

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title = "Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres",

abstract = "Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.",

author = "Min Zhu and Yanyan Yu and Junfeng Zhu and Yao Zhou and Gaoxing Su and Hongyan Zhu and Yong Chen and Mingkai Liu",

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AU - Zhu, Min

AU - Yu, Yanyan

AU - Zhu, Junfeng

AU - Zhou, Yao

AU - Su, Gaoxing

AU - Zhu, Hongyan

AU - Chen, Yong

AU - Liu, Mingkai

PY - 2020/8/7

Y1 - 2020/8/7

N2 - Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

AB - Toehold exchange spherical nucleic acids (TESNA) modulated on molybdenum disulfide (MoS2) acanthospheres were proposed for the discrimination of single nucleotide variants (SNVs). We rationally optimized the probe by making a trade-off between the discrimination factor (DF) and hybridization ratio (χ). The TESNA platform can distinguish SNVs with significantly improved sensitivity and specificity.

UR - https://www.scopus.com/pages/publications/85089127271

U2 - 10.1039/d0cc03425h

DO - 10.1039/d0cc03425h

M3 - 文章

C2 - 32678380

AN - SCOPUS:85089127271

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Single nucleotide variant discrimination by toehold exchange spherical nucleic acids modulated on hierarchical molybdenum disulfide acanthospheres

Abstract

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