Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways

Lei Zhang; Yang Li; Da Wei Li; Chao Jing; Xiaoyuan Chen; Min Lv; Qing Huang; Yi Tao Long; Itamar Willner

doi:10.1002/anie.201102151

Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways

Lei Zhang
, Yang Li
, Da Wei Li
, Chao Jing
, Xiaoyuan Chen
, Min Lv
, Qing Huang
, Yi Tao Long^*
, Itamar Willner

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

158 Scopus citations

Abstract

A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.

Original language	English
Pages (from-to)	6789-6792
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	50
Issue number	30
DOIs	https://doi.org/10.1002/anie.201102151
State	Published - 18 Jul 2011
Externally published	Yes

Keywords

NADH
gold nanoparticles
metabolic pathways
plasmon resonance Rayleigh scattering

Access to Document

10.1002/anie.201102151

Cite this

@article{ede7ca08a1914bf6bb4df39d12a1bbf1,

title = "Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways",

abstract = "A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.",

keywords = "NADH, gold nanoparticles, metabolic pathways, plasmon resonance Rayleigh scattering",

author = "Lei Zhang and Yang Li and Li, \{Da Wei\} and Chao Jing and Xiaoyuan Chen and Min Lv and Qing Huang and Long, \{Yi Tao\} and Itamar Willner",

year = "2011",

month = jul,

day = "18",

doi = "10.1002/anie.201102151",

language = "英语",

volume = "50",

pages = "6789--6792",

journal = "Angewandte Chemie - International Edition",

issn = "1433-7851",

publisher = "John Wiley and Sons Ltd",

number = "30",

}

TY - JOUR

T1 - Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways

AU - Zhang, Lei

AU - Li, Yang

AU - Li, Da Wei

AU - Jing, Chao

AU - Chen, Xiaoyuan

AU - Lv, Min

AU - Huang, Qing

AU - Long, Yi Tao

AU - Willner, Itamar

PY - 2011/7/18

Y1 - 2011/7/18

N2 - A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.

AB - A coat of many colors: Plasmon resonance Rayleigh scattering (PRRS) spectroscopy is applied to the in-situ monitoring of the NADH-dependent growth of Au@Cu core-shell nanoparticles (NPs). The scattering signal of the AuNPs is red shifted when they are coated with Cu (see scheme). In conjunction with dark-field microscopy, a colorimetric NADH-dependent biosensor was constructed and tested to screen an anticancer drug affecting cell NADH metabolism.

KW - NADH

KW - gold nanoparticles

KW - metabolic pathways

KW - plasmon resonance Rayleigh scattering

UR - https://www.scopus.com/pages/publications/79960248066

U2 - 10.1002/anie.201102151

DO - 10.1002/anie.201102151

M3 - 文章

C2 - 21661084

AN - SCOPUS:79960248066

SN - 1433-7851

VL - 50

SP - 6789

EP - 6792

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 30

ER -

Single gold nanoparticles as real-time optical probes for the detection of NADH-dependent intracellular metabolic enzymatic pathways

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this