Simple Ether-Directed Enantioselective C(sp3)−H Borylation of Cyclopropanes Enabled by Iridium Catalysis

Tian Xie; Lili Chen; Zhenlu Shen; Senmiao Xu

doi:10.1002/anie.202300199

Simple Ether-Directed Enantioselective C(sp³)−H Borylation of Cyclopropanes Enabled by Iridium Catalysis

Tian Xie, Lili Chen, Zhenlu Shen^*, Senmiao Xu^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Reported here is an efficient and simple ether-directed iridium-catalyzed enantioselective C(sp³)−H borylation of cyclopropanes. Various functional groups were well-tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.

Original language	English
Article number	e202300199
Journal	Angewandte Chemie - International Edition
Volume	62
Issue number	14
DOIs	https://doi.org/10.1002/anie.202300199
State	Published - 27 Mar 2023
Externally published	Yes

Keywords

Asymmetric Catalysis
Chiral Bidentate Boryl Ligand
Cyclopropane
C−H Borylation
Synthetic Method

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10.1002/anie.202300199

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title = "Simple Ether-Directed Enantioselective C(sp3)−H Borylation of Cyclopropanes Enabled by Iridium Catalysis",

abstract = "Reported here is an efficient and simple ether-directed iridium-catalyzed enantioselective C(sp3)−H borylation of cyclopropanes. Various functional groups were well-tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.",

keywords = "Asymmetric Catalysis, Chiral Bidentate Boryl Ligand, Cyclopropane, C−H Borylation, Synthetic Method",

author = "Tian Xie and Lili Chen and Zhenlu Shen and Senmiao Xu",

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year = "2023",

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doi = "10.1002/anie.202300199",

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AU - Xie, Tian

AU - Chen, Lili

AU - Shen, Zhenlu

AU - Xu, Senmiao

PY - 2023/3/27

Y1 - 2023/3/27

N2 - Reported here is an efficient and simple ether-directed iridium-catalyzed enantioselective C(sp3)−H borylation of cyclopropanes. Various functional groups were well-tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.

AB - Reported here is an efficient and simple ether-directed iridium-catalyzed enantioselective C(sp3)−H borylation of cyclopropanes. Various functional groups were well-tolerated, affording a vast array of chiral cyclopropanes with high enantioselectivities. We also demonstrated that the turnover numbers of the current reaction could be up to 335.

KW - Asymmetric Catalysis

KW - Chiral Bidentate Boryl Ligand

KW - Cyclopropane

KW - C−H Borylation

KW - Synthetic Method

UR - https://www.scopus.com/pages/publications/85148634724

U2 - 10.1002/anie.202300199

DO - 10.1002/anie.202300199

M3 - 文章

C2 - 36762972

AN - SCOPUS:85148634724

SN - 1433-7851

VL - 62

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 14

M1 - e202300199

ER -

Simple Ether-Directed Enantioselective C(sp³)−H Borylation of Cyclopropanes Enabled by Iridium Catalysis

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Keywords

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