Silencing of E6/E7 expression in cervical cancer stem- like cells

Wenyi Gu; Nigel McMillan; Chengzhong Yu

doi:10.1007/978-1-4939-2013-6_12

Silencing of E6/E7 expression in cervical cancer stem- like cells

Wenyi Gu^*
, Nigel McMillan
, Chengzhong Yu

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

1 Scopus citations

Abstract

Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

Original language	English
Title of host publication	Cervical Cancer
Subtitle of host publication	Methods and Protocols
Publisher	Springer New York
Pages	173-182
Number of pages	10
ISBN (Electronic)	9781493920136
ISBN (Print)	9781493920129
DOIs	https://doi.org/10.1007/978-1-4939-2013-6_12
State	Published - 27 Oct 2014
Externally published	Yes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Cancer stem cells
Gene silence
HPV E6/E7
RNAi

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10.1007/978-1-4939-2013-6_12

Cite this

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title = "Silencing of E6/E7 expression in cervical cancer stem- like cells",

abstract = "Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.",

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T1 - Silencing of E6/E7 expression in cervical cancer stem- like cells

AU - Gu, Wenyi

AU - McMillan, Nigel

AU - Yu, Chengzhong

N1 - Publisher Copyright: © Springer Science+Business Media New York 2015. All rights are reserved.

PY - 2014/10/27

Y1 - 2014/10/27

N2 - Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

AB - Accumulating evidence supports the concept that cancer stem cells (CSCs) are responsible for the tumor recurrence and metastasis, the two major causes of cancer-related death. Therefore, CSC-targeted cancer therapy is important for the future development of more effective and advanced cancer therapy. One of the approaches is to specifically silence oncogene expression in CSCs and inhibit their growth. The significance of this approach is its specificity and ability to avoid multi-drug resistance of CSCs. In this chapter, we will describe a method of silencing HPV oncogenes E6/E7 in human cervical CSCs using HeLa cells as a model system.

KW - Cancer stem cells

KW - Gene silence

KW - HPV E6/E7

KW - RNAi

UR - https://www.scopus.com/pages/publications/84921744522

U2 - 10.1007/978-1-4939-2013-6_12

DO - 10.1007/978-1-4939-2013-6_12

M3 - 章节

AN - SCOPUS:84921744522

SN - 9781493920129

SP - 173

EP - 182

BT - Cervical Cancer

PB - Springer New York

ER -

Silencing of E6/E7 expression in cervical cancer stem- like cells

Abstract

UN SDGs

Keywords

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