Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

Bin Wang; Rizhao Pan; Weiping Zhu; Yufang Xu; Ye Tian; Masayuki Endo; Hiroshi Sugiyama; Yangyang Yang; Xuhong Qian

doi:10.1039/d0sm01817a

Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

Bin Wang
, Rizhao Pan
, Weiping Zhu
, Yufang Xu
, Ye Tian
, Masayuki Endo
, Hiroshi Sugiyama
, Yangyang Yang^*
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology
Nanjing University
Kyoto University

Research output: Contribution to journal › Article › peer-review

13 Scopus citations

Abstract

A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.

Original language	English
Pages (from-to)	1184-1188
Number of pages	5
Journal	Soft Matter
Volume	17
Issue number	5
DOIs	https://doi.org/10.1039/d0sm01817a
State	Published - 7 Feb 2021
Externally published	Yes

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10.1039/d0sm01817a

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title = "Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability",

abstract = "A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.",

author = "Bin Wang and Rizhao Pan and Weiping Zhu and Yufang Xu and Ye Tian and Masayuki Endo and Hiroshi Sugiyama and Yangyang Yang and Xuhong Qian",

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T1 - Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

AU - Wang, Bin

AU - Pan, Rizhao

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Tian, Ye

AU - Endo, Masayuki

AU - Sugiyama, Hiroshi

AU - Yang, Yangyang

AU - Qian, Xuhong

PY - 2021/2/7

Y1 - 2021/2/7

N2 - A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.

AB - A series of short intrinsically disordered polypeptide conjugated oligonucleotides (IDPOCs) were rationally developed and assembled into well-defined nanospheres. The nanospheres exhibited excellent reversible thermoresponsive regulation of their contraction and expansion. Furthermore, the nanospheres showed biocompatibility, drug encapsulation and effective cellular uptake.

UR - https://www.scopus.com/pages/publications/85101445641

U2 - 10.1039/d0sm01817a

DO - 10.1039/d0sm01817a

M3 - 文章

C2 - 33527954

AN - SCOPUS:85101445641

SN - 1744-683X

VL - 17

SP - 1184

EP - 1188

JO - Soft Matter

JF - Soft Matter

IS - 5

ER -

Short intrinsically disordered polypeptide-oligonucleotide conjugates for programmed self-assembly of nanospheres with temperature-dependent size controllability

Abstract

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