Sesquiterpenoids from Inula racemosa Hookf. Inhibit nitric oxide production

Shou De Zhang; Jiang Jiang Qin; Hui Zi Jin; Yin Hua Yin; Hong Lin Li; Xian Wen Yang; Xia Li; Lei Shan; Wei Dong Zhang

doi:10.1055/s-0031-1280294

Sesquiterpenoids from Inula racemosa Hookf. Inhibit nitric oxide production

Shou De Zhang, Jiang Jiang Qin, Hui Zi Jin, Yin Hua Yin, Hong Lin Li, Xian Wen Yang, Xia Li, Lei Shan, Wei Dong Zhang

Research output: Contribution to journal › Article › peer-review

32 Scopus citations

Abstract

A novel trinorsesquiterpene (1), three new (24), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC ₅₀ values of 7.39±0.36, 6.35±0.26, and 5.39±0.18μM, respectively.

Original language	English
Pages (from-to)	166-171
Number of pages	6
Journal	Planta Medica
Volume	78
Issue number	2
DOIs	https://doi.org/10.1055/s-0031-1280294
State	Published - 2012
Externally published	Yes

Keywords

Compositae
Inula racemosa Hook. f.
density functional theory
nitric oxide
sesquiterpenes

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10.1055/s-0031-1280294

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title = "Sesquiterpenoids from Inula racemosa Hookf. Inhibit nitric oxide production",

abstract = "A novel trinorsesquiterpene (1), three new (24), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC 50 values of 7.39±0.36, 6.35±0.26, and 5.39±0.18μM, respectively.",

keywords = "Compositae, Inula racemosa Hook. f., density functional theory, nitric oxide, sesquiterpenes",

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doi = "10.1055/s-0031-1280294",

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publisher = "Georg Thieme Verlag",

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T1 - Sesquiterpenoids from Inula racemosa Hookf. Inhibit nitric oxide production

AU - Zhang, Shou De

AU - Qin, Jiang Jiang

AU - Jin, Hui Zi

AU - Yin, Yin Hua

AU - Li, Hong Lin

AU - Yang, Xian Wen

AU - Li, Xia

AU - Shan, Lei

AU - Zhang, Wei Dong

PY - 2012

Y1 - 2012

N2 - A novel trinorsesquiterpene (1), three new (24), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC 50 values of 7.39±0.36, 6.35±0.26, and 5.39±0.18μM, respectively.

AB - A novel trinorsesquiterpene (1), three new (24), and 10 known sesquiterpenes were isolated from the roots of Inula racemosa Hook. f. The structures and absolute configurations of the new sesquiterpenes were elucidated by extensive spectroscopic and computational methods. All compounds were evaluated for their inhibition of LPS-induced nitric oxide production in RAW264.7 macrophages, and the results indicated that compounds 9, 12, and 13 moderately inhibited nitric oxide production with IC 50 values of 7.39±0.36, 6.35±0.26, and 5.39±0.18μM, respectively.

KW - Compositae

KW - Inula racemosa Hook. f.

KW - density functional theory

KW - nitric oxide

KW - sesquiterpenes

UR - https://www.scopus.com/pages/publications/84856306164

U2 - 10.1055/s-0031-1280294

DO - 10.1055/s-0031-1280294

M3 - 文章

C2 - 22002850

AN - SCOPUS:84856306164

SN - 0032-0943

VL - 78

SP - 166

EP - 171

JO - Planta Medica

JF - Planta Medica

IS - 2

ER -

Sesquiterpenoids from Inula racemosa Hookf. Inhibit nitric oxide production

Abstract

Keywords

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