Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis

Xin Chen; Zha Jun Zhan; Xiong Wen Zhang; Jian Ding; Jian Min Yue

doi:10.1055/s-2005-871212

Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis

Xin Chen
, Zha Jun Zhan
, Xiong Wen Zhang
, Jian Ding
, Jian Min Yue^*

^*Corresponding author for this work

CAS - Shanghai Institute of Materia Medica

Research output: Contribution to journal › Article › peer-review

19 Scopus citations

Abstract

Five new sesquiterpene lactones, namely vernchinilides A - E(1-5), along with five known compounds, 8β-(2-methylacryloyloxy)-hirsutinolide 13-O-acetate (6), 8α-(2-methylacryloyloxy)-1β4β-epoxy-1α- methoxy-13-O-acetate-10βH-germacra-5E,7(11)-dien-12,6-olide (7), 8β-(2-hydroxymethylacryloyloxy)hirsutinolide 13-O-acetate (8), 8α-tigloyloxyhirsutinolide 13-O-acetate (9) and vernolide-B (10) were isolated from Vernonia chinensis. The structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques. Compounds 2,5 and 6 exhibited potent cytotoxic activities against P-388 and A-549 tumor cell lines.

Original language	English
Pages (from-to)	949-954
Number of pages	6
Journal	Planta Medica
Volume	71
Issue number	10
DOIs	https://doi.org/10.1055/s-2005-871212
State	Published - Oct 2005
Externally published	Yes

Keywords

Cytotoxic activity
Hirsutinolides
Sesquiterpenes
Vernchinilides A - E
Vernonia chinensis

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10.1055/s-2005-871212

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@article{b2feeb67f470408c813cde93cc972df3,

title = "Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis",

abstract = "Five new sesquiterpene lactones, namely vernchinilides A - E(1-5), along with five known compounds, 8β-(2-methylacryloyloxy)-hirsutinolide 13-O-acetate (6), 8α-(2-methylacryloyloxy)-1β4β-epoxy-1α- methoxy-13-O-acetate-10βH-germacra-5E,7(11)-dien-12,6-olide (7), 8β-(2-hydroxymethylacryloyloxy)hirsutinolide 13-O-acetate (8), 8α-tigloyloxyhirsutinolide 13-O-acetate (9) and vernolide-B (10) were isolated from Vernonia chinensis. The structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques. Compounds 2,5 and 6 exhibited potent cytotoxic activities against P-388 and A-549 tumor cell lines.",

keywords = "Cytotoxic activity, Hirsutinolides, Sesquiterpenes, Vernchinilides A - E, Vernonia chinensis",

author = "Xin Chen and Zhan, \{Zha Jun\} and Zhang, \{Xiong Wen\} and Jian Ding and Yue, \{Jian Min\}",

year = "2005",

month = oct,

doi = "10.1055/s-2005-871212",

language = "英语",

volume = "71",

pages = "949--954",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "Georg Thieme Verlag",

number = "10",

}

TY - JOUR

T1 - Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis

AU - Chen, Xin

AU - Zhan, Zha Jun

AU - Zhang, Xiong Wen

AU - Ding, Jian

AU - Yue, Jian Min

PY - 2005/10

Y1 - 2005/10

N2 - Five new sesquiterpene lactones, namely vernchinilides A - E(1-5), along with five known compounds, 8β-(2-methylacryloyloxy)-hirsutinolide 13-O-acetate (6), 8α-(2-methylacryloyloxy)-1β4β-epoxy-1α- methoxy-13-O-acetate-10βH-germacra-5E,7(11)-dien-12,6-olide (7), 8β-(2-hydroxymethylacryloyloxy)hirsutinolide 13-O-acetate (8), 8α-tigloyloxyhirsutinolide 13-O-acetate (9) and vernolide-B (10) were isolated from Vernonia chinensis. The structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques. Compounds 2,5 and 6 exhibited potent cytotoxic activities against P-388 and A-549 tumor cell lines.

AB - Five new sesquiterpene lactones, namely vernchinilides A - E(1-5), along with five known compounds, 8β-(2-methylacryloyloxy)-hirsutinolide 13-O-acetate (6), 8α-(2-methylacryloyloxy)-1β4β-epoxy-1α- methoxy-13-O-acetate-10βH-germacra-5E,7(11)-dien-12,6-olide (7), 8β-(2-hydroxymethylacryloyloxy)hirsutinolide 13-O-acetate (8), 8α-tigloyloxyhirsutinolide 13-O-acetate (9) and vernolide-B (10) were isolated from Vernonia chinensis. The structures of these new compounds were elucidated on the basis of spectral data, especially 2D-NMR techniques. Compounds 2,5 and 6 exhibited potent cytotoxic activities against P-388 and A-549 tumor cell lines.

KW - Cytotoxic activity

KW - Hirsutinolides

KW - Sesquiterpenes

KW - Vernchinilides A - E

KW - Vernonia chinensis

UR - https://www.scopus.com/pages/publications/27844449991

U2 - 10.1055/s-2005-871212

DO - 10.1055/s-2005-871212

M3 - 文章

C2 - 16254828

AN - SCOPUS:27844449991

SN - 0032-0943

VL - 71

SP - 949

EP - 954

JO - Planta Medica

JF - Planta Medica

IS - 10

ER -

Sesquiterpene lactones with potent cytotoxic activities from Vernonia chinensis

Abstract

Keywords

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