Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

Fengjuan Xie; Yingying Lin; Åsa Andersson; Irina Vetter; Liang Zhao; Jing Jing Wan

doi:10.1039/d3cc03801g

Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

Fengjuan Xie, Yingying Lin, Åsa Andersson, Irina Vetter, Liang Zhao, Jing Jing Wan

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.

Original language	English
Pages (from-to)	13855-13858
Number of pages	4
Journal	Chemical Communications
Volume	59
Issue number	93
DOIs	https://doi.org/10.1039/d3cc03801g
State	Published - 26 Oct 2023

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abstract = "Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.",

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AU - Xie, Fengjuan

AU - Lin, Yingying

AU - Andersson, Åsa

AU - Vetter, Irina

AU - Zhao, Liang

AU - Wan, Jing Jing

PY - 2023/10/26

Y1 - 2023/10/26

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AB - Herein, we designed alkylated lysine-dendron oxytocin amphiphiles (ALOAs) 1G-OTK and 2G-OTK, which were self-assembled into spherical nanoparticles and nanostrips, respectively, and showed superior stability compared to native oxytocin. We found similar trends in the functional activity of ALOAs and native OT for human oxytocin receptor. This work may inspire the development of peptide drugs for clinical applications.

UR - https://www.scopus.com/pages/publications/85176229492

U2 - 10.1039/d3cc03801g

DO - 10.1039/d3cc03801g

M3 - 文章

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AN - SCOPUS:85176229492

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Self-assembly of alkylated lysine-dendron oxytocin amphiphiles for enhanced stability and sustained pharmacological activity

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