Selective detection of homocysteine by using poly methyl vinyl ether-alt-maleic silver clusters

Taiqun Yang; Shan Dai; Cuifang Qin; Kehan Huang; Yuting Chen; Haifeng Pan; Sanjun Zhang; Kun Zhang; Jianhua Xu

doi:10.6023/cjoc201511023

Selective detection of homocysteine by using poly methyl vinyl ether-alt-maleic silver clusters

Taiqun Yang
, Shan Dai
, Cuifang Qin
, Kehan Huang
, Yuting Chen
, Haifeng Pan
, Sanjun Zhang^*
, Kun Zhang
, Jianhua Xu

^*Corresponding author for this work

School of Chemistry and Molecular Engineering

Research output: Contribution to journal › Comment/debate

1 Scopus citations

Abstract

We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.

Original language	English
Pages (from-to)	867-871
Number of pages	5
Journal	Chinese Journal of Organic Chemistry
Volume	36
Issue number	4
DOIs	https://doi.org/10.6023/cjoc201511023
State	Published - 1 Apr 2016

Keywords

Fluorescent sensor
Homocysteine
Poly methyl vinyl ether-alt-maleic acid
Silver nanoclusters

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10.6023/cjoc201511023

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@article{1a4d2c4bce544107a55dab0eebcd2826,

title = "Selective detection of homocysteine by using poly methyl vinyl ether-alt-maleic silver clusters",

abstract = "We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.",

keywords = "Fluorescent sensor, Homocysteine, Poly methyl vinyl ether-alt-maleic acid, Silver nanoclusters",

author = "Taiqun Yang and Shan Dai and Cuifang Qin and Kehan Huang and Yuting Chen and Haifeng Pan and Sanjun Zhang and Kun Zhang and Jianhua Xu",

note = "Publisher Copyright: {\textcopyright} 2016 Chinese Chemical Society \& SIOC, CAS.",

year = "2016",

month = apr,

day = "1",

doi = "10.6023/cjoc201511023",

language = "英语",

volume = "36",

pages = "867--871",

journal = "Chinese Journal of Organic Chemistry",

issn = "0253-2786",

publisher = "Science Press ",

number = "4",

}

TY - JOUR

T1 - Selective detection of homocysteine by using poly methyl vinyl ether-alt-maleic silver clusters

AU - Yang, Taiqun

AU - Dai, Shan

AU - Qin, Cuifang

AU - Huang, Kehan

AU - Chen, Yuting

AU - Pan, Haifeng

AU - Zhang, Sanjun

AU - Zhang, Kun

AU - Xu, Jianhua

PY - 2016/4/1

Y1 - 2016/4/1

N2 - We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.

AB - We report selective detection of homocysteine (Hcy) through luminescent poly methyl vinyl ether-alt-maleic acid (PMVEM) silver nanoclusters (Ag NCs), which were synthesized using PMVEM as scaffold. The as-developed PMVEM-Ag NCs have two emission peaks at 460 and 540 nm. After Hcy was added, the thiol moiety of Hcy can efficiently coordinate on Ag NCs, resulting in luminescence quenching of the 460 and 540 nm peaks. However, the ratio of these two emission peak was linearly correlated with the Hcy concentration from 5 to 100 μmol/L. The detection limits was 1 μmol/L. The detection of Hcy used the ratio of the two emission peaks, which permit selective detection of Hcy and quantitive determination of Hcy levels.

KW - Fluorescent sensor

KW - Homocysteine

KW - Poly methyl vinyl ether-alt-maleic acid

KW - Silver nanoclusters

UR - https://www.scopus.com/pages/publications/84969567310

U2 - 10.6023/cjoc201511023

DO - 10.6023/cjoc201511023

M3 - 评论/辩论

AN - SCOPUS:84969567310

SN - 0253-2786

VL - 36

SP - 867

EP - 871

JO - Chinese Journal of Organic Chemistry

JF - Chinese Journal of Organic Chemistry

IS - 4

ER -

Selective detection of homocysteine by using poly methyl vinyl ether-alt-maleic silver clusters

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Keywords

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