TY - JOUR
T1 - Selective C-O Bond Forming Reactions at Indole-C2-Position toward Polycyclic Indolone or Indolinone Derivatives Tethered with Medium-Sized Rings
AU - Wang, Zongkang
AU - Yin, Liqiang
AU - Wang, Mengdan
AU - Zhu, Yilin
AU - Yang, Yajie
AU - Cheng, Lu
AU - Wang, Chengyu
AU - Li, Yanzhong
N1 - Publisher Copyright:
© 2022 American Chemical Society. All rights reserved.
PY - 2022/9/2
Y1 - 2022/9/2
N2 - A methodology involving the chemoselective synthesis of tetracyclic [1,3]oxazino[3,2-a]indol-4-one or tetracyclic [1,3]oxazino[3,2-a]indoline-4-one tethered with a medium-sized ring by cross dehydrogenative coupling (CDC) or nucleophilic addition (NA) reaction has been developed. [1,3]Oxazino[3,2-a]indol-4-one compounds fused with a medium-sized ring were constructed through a CDC reaction in the presence of I2and K2CO3. Whereas, [1,3]oxazino[3,2-a]indoline-4-ones tethered with a medium-sized ring were obtained with a TfOH system by NA reaction.
AB - A methodology involving the chemoselective synthesis of tetracyclic [1,3]oxazino[3,2-a]indol-4-one or tetracyclic [1,3]oxazino[3,2-a]indoline-4-one tethered with a medium-sized ring by cross dehydrogenative coupling (CDC) or nucleophilic addition (NA) reaction has been developed. [1,3]Oxazino[3,2-a]indol-4-one compounds fused with a medium-sized ring were constructed through a CDC reaction in the presence of I2and K2CO3. Whereas, [1,3]oxazino[3,2-a]indoline-4-ones tethered with a medium-sized ring were obtained with a TfOH system by NA reaction.
UR - https://www.scopus.com/pages/publications/85136639930
U2 - 10.1021/acs.orglett.2c02398
DO - 10.1021/acs.orglett.2c02398
M3 - 文章
C2 - 35980745
AN - SCOPUS:85136639930
SN - 1523-7060
VL - 24
SP - 6272
EP - 6276
JO - Organic Letters
JF - Organic Letters
IS - 34
ER -