Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

Lei Cui; Ye Zhong; Weiping Zhu; Yufang Xu; Xuhong Qian

doi:10.1039/c0cc01000f

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

Lei Cui^*
, Ye Zhong
, Weiping Zhu
, Yufang Xu
, Xuhong Qian

^*Corresponding author for this work

East China University of Science and Technology

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

Original language	English
Pages (from-to)	7121-7123
Number of pages	3
Journal	Chemical Communications
Volume	46
Issue number	38
DOIs	https://doi.org/10.1039/c0cc01000f
State	Published - 14 Oct 2010
Externally published	Yes

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title = "Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe",

abstract = "A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.",

author = "Lei Cui and Ye Zhong and Weiping Zhu and Yufang Xu and Xuhong Qian",

year = "2010",

month = oct,

day = "14",

doi = "10.1039/c0cc01000f",

language = "英语",

volume = "46",

pages = "7121--7123",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

AU - Cui, Lei

AU - Zhong, Ye

AU - Zhu, Weiping

AU - Xu, Yufang

AU - Qian, Xuhong

PY - 2010/10/14

Y1 - 2010/10/14

N2 - A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

AB - A novel NAT2 specific probe has been developed for sensitive detection of the activity of NAT2. Upon NAT2 catalyzed acetylation of the molecule to N-acetyl-amonafide, the ratiometric response of fluorescence with significant changes in wavelength and intensity is observed. Its significant application potential has been successfully demonstrated in cellular systems.

UR - https://www.scopus.com/pages/publications/77956825142

U2 - 10.1039/c0cc01000f

DO - 10.1039/c0cc01000f

M3 - 文章

C2 - 20798904

AN - SCOPUS:77956825142

SN - 1359-7345

VL - 46

SP - 7121

EP - 7123

JO - Chemical Communications

JF - Chemical Communications

IS - 38

ER -

Selective and sensitive detection and quantification of arylamine N-acetyltransferase 2 by a ratiometric fluorescence probe

Abstract

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