SDS-MoS₂ nanoparticles as highly-efficient peroxidase mimetics for colorimetric detection of H₂O₂ and glucose

In this work, we find that the peroxidase-like activity of MoS₂ nanoparticles (NPs) is dependent on the surface charge. Negatively charged sodium dodecyl sulfate modified MoS₂ nanoparticles (SDS-MoS₂ NPs) possess highly-efficient peroxidase-like activity. MoS₂ NPs with intrinsic peroxidase-like activity were synthesized through a simple one-pot hydrothermal route. The peroxidase-like activities of different surfactants modified MoS₂ NPs were discussed. Compared with bare MoS₂ NPs and positively charged cetyltrimethyl ammonium bromide modified MoS₂ NPs, SDS-MoS₂ NPs have the best peroxidase-like activity. SDS-MoS₂ NPs can efficiently catalyze the oxidation of 3,3,5,5-tetramethylbenzidine (TMB) in the presence of H₂O₂ to generate a blue product. On basis of this, we have successfully established a novel platform for colorimetric detection of H₂O₂, and the detection limit is 0.32 μM. Furthermore, the SDS-MoS₂ NPs based platform can also be used for high sensitivity and selectivity detection of glucose with a wide linear range of 5.0-500 μM by controlling the generation of H₂O₂ in the presence of glucose oxidase.